DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and Cpxm2

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_061355.3	Gene:	Cpxm2 / 55987	MGIID:	1926006	Length:	764	Species:	Mus musculus

Alignment Length:	419	Identity:	151/419 - (36%)
Similarity:	224/419 - (53%)	Gaps:	56/419 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPEPRAY------MPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVS 113
            ||:|..|      |.....|||.:|:::|:.:.::..:...||:|.:|:||||.||..|:.:.:|
Mouse   303 LPDPNNYYHRRNEMTTTDDLDFKHHNYKEMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEIS 367

  Fly   114 SSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDNTRIHILPTMNP 177
            ..|.||.||:|:..|:...||||.:|||:||.|:.:....|:. :..:..|::.|||||||::||
Mouse   368 DHPGEHEVGEPEFHYIAGAHGNEVLGRELLLLLLHFLCQEYSAQNARIVRLVEETRIHILPSLNP 432

  Fly   178 DGYAVSKEGTCD-GG--QGRYNARGFDLNRNFPD---------------------------YFKQ 212
            |||..:.||..: ||  .||:...|.|:|.||||                           :|..
Mouse   433 DGYEKAYEGGSELGGWSLGRWTHDGIDINNNFPDLNSLLWEAEDQQNAPRKVPNHYIAIPEWFLS 497

  Fly   213 NNKRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSA 277
            .|.....||.:|..|:.||.|||.|:|.||.||.:||||          :.||     :::|...
Mouse   498 ENATVATETRAVIAWMEKIPFVLGGNLQGGELVVAYPYD----------MVRS-----LWKTQEH 547

  Fly   278 APSLTPDDDVFKHLSLVYARNHAKM--SRGVACKSATPAFENGITNGAAWYPLTGGMQDYNYVWY 340
            .|  ||||.||:.|:..||..|..|  :|...|.:.....|.|..|||:|:.:.|.:.|::|:..
Mouse   548 TP--TPDDHVFRWLAYSYASTHRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHT 610

  Fly   341 GCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKIKGRD 405
            .|.|:::.:.|.|:|...||.:.||:|:.|||.|:.:.|||::|.|.|..|..|..|.|.::|.:
Mouse   611 NCFELSIYVGCDKYPHESELPEEWENNRESLIVFMEQVHRGIKGIVRDLQGKGISNAVISVEGVN 675

  Fly   406 VGFQTTKYGEFWRILLPGYYKVEVFAEGF 434
            ...:|...|::||:|.||.|.|...||||
Mouse   676 HDIRTASDGDYWRLLNPGEYVVTAKAEGF 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	119/337 (35%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	22/54 (41%)
Cpxm2	NP_061355.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..136
		FA58C	145..300	CDD:238014
		FA58C	146..301	CDD:214572
		M14_CPX_like	322..647	CDD:199851	122/341 (36%)
		Peptidase_M14NE-CP-C_like	651..726	CDD:200604	22/54 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820