DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and cpdb

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001315329.1	Gene:	cpdb / 555848	ZFINID:	ZDB-GENE-060929-1270	Length:	1275	Species:	Danio rerio

Alignment Length:	433	Identity:	151/433 - (34%)
Similarity:	243/433 - (56%)	Gaps:	54/433 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNE 136
            |:::.|:|..|:..|.::|.:.:|.|||:|::.|:||||.::|:|.:.:.|||.|||||||||:|
Zfish    35 YYNYAEMTDRLKGFSRKFPRICSLASIGQSVEDRELWVMRITSNPTQDVPGKPKVKYVGNIHGDE 99

  Fly   137 PVGREMLLHLIQYFVTSYNTDQYVKWLLDNTRIHILPTMNPDGYAVSKEGTCDG-GQGRYNARGF 200
            .:.|::|::|::|.:|.|..|..|..|:|.|.|:||.:|||||:..:.||.|.| .:.|.||:.:
Zfish   100 ALSRQVLVYLVEYLLTRYGRDVRVTELVDRTDIYILASMNPDGFERALEGECSGTTEARDNAKNY 164

  Fly   201 DLNRNFP--DYFKQNNKRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGIC 263
            |||::||  |..........||..:|..||.:.:||||||||||:::||||:::
Zfish   165 DLNKSFPVQDEPSSETAGDIPEVMAVIRWIQERKFVLSGSLHGGSVMASYPFED----------- 218

  Fly   264 RSSALCAMFQTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFENGITNGAAWYPL 328
                        .::.:.:.||.:|::|:..|..||..|....|.....|...:|
Zfish   219 ------------DSSYTRSGDDALFRNLAQAYIENHPVMGTNNADCPDDPNKSSG---------- 261

  Fly   329 TGGMQDYNYVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMP 393
            .|.||||||:...|.|::.|:||||:|||.:|...|.:|:.:|:.|:.:||.||:|||.:.:|:.
Zfish   262 EGSMQDYNYLKGNCFEVSFELSCCKYPPASQLYTEWSNNREALLAFIQKAHIGVRGFVLNKSGLG 326

  Fly   394 IERASIKIKGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPREVEFV-IVEQHPTLLNVTL-Q 456
            :..|:|.:.|.|....|.|:|:::|:||||.|.:...:.|:....|..| :::....|:|.|| :
Zfish   327 LPDATISVSGIDHNITTWKFGDYYRLLLPGKYDITASSPGYLSNTVMNVPVIDGRVMLVNFTLEE 391

  Fly   457 PSKRLEGIGPMGPGGVPVGGVVGPGGLYRPIPSPQHYRPPVPP 499
            |.:.:..:...|                :||.:.|....|.||
Zfish   392 PLEEMLMLDTFG----------------QPIITHQDLNTPAPP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	115/307 (37%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	24/74 (32%)
cpdb	NP_001315329.1	Peptidase_M14_like	35..310	CDD:299699	115/307 (37%)
		Peptidase_M14NE-CP-C_like	314..389	CDD:200604	24/74 (32%)
		Peptidase_M14_like	431..712	CDD:299699
		Peptidase_M14NE-CP-C_like	717..791	CDD:200604
		Peptidase_M14_like	835..1113	CDD:299699
		Peptidase_M14NE-CP-C_like	1120..1192	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.780