DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and cpm

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001017591.1	Gene:	cpm / 550253	ZFINID:	ZDB-GENE-041210-191	Length:	446	Species:	Danio rerio

Alignment Length:	417	Identity:	181/417 - (43%)
Similarity:	253/417 - (60%)	Gaps:	52/417 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLLLMLHLLLCDAKTVNPGDSMQMQHHQMTAEPGLPEPRAYMPDAQHLDFVYHDHEELTRFLRAT 85
            :|:.|..||.|.:                             .||  |:|.||:..::.::|:..
Zfish     1 MLVFMFCLLFCSS-----------------------------TDA--LEFRYHNTVQMEQYLKDV 34

  Fly    86 SARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYF 150
            :..||::|.|:|||:|::||:|||:::...|.||..|.|:.||||||||||.|||.:||.|:.|.
Zfish    35 NKMYPHITHLHSIGQSVEGRELWVLILGQHPREHRTGIPEFKYVGNIHGNEVVGRVLLLQLVNYL 99

  Fly   151 VTSYNTDQYVKWLLDNTRIHILPTMNPDGYAVSKEGTCDGGQGRYNARGFDLNRNFPDYFKQ-NN 214
            .:.|.:|..|..|||::|:||||:|||||:..||. .|....||||..|.||||||||.|:: |.
Zfish   100 TSHYGSDSVVTRLLDSSRVHILPSMNPDGFESSKP-DCIYTVGRYNKNGVDLNRNFPDAFEEGNE 163

  Fly   215 KRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAP 279
            ::.:.|..:|.:|:....||||.:||||||||||||||:......:|.                .
Zfish   164 QKRESEVRAVMEWLKSETFVLSANLHGGALVASYPYDNSNGGSEQQGY----------------R 212

  Fly   280 SLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFENGITNGAAWYPLTGGMQDYNYVWYGCME 344
            |::||||||.||:..|:.||.::.||..| |...:|.:|||||..||||.||||||||||..|:|
Zfish   213 SVSPDDDVFVHLAKTYSYNHTEVYRGNHC-SDLQSFSSGITNGYQWYPLQGGMQDYNYVWAQCLE 276

  Fly   345 ITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKIKGRD--VG 407
            :|||||||||||..:|...||.|:.:|:.::.:.|.|::|.|.|.:|..|..|.:::.||:  ..
Zfish   277 LTLEISCCKFPPEEQLPALWEANRAALLAYMQQVHLGLKGVVMDSSGQIIPHAVVEVLGRNNLCA 341

  Fly   408 FQTTKYGEFWRILLPGYYKVEVFAEGF 434
            ||:...||::|:||||.|.::|.|.||
Zfish   342 FQSDVNGEYFRLLLPGKYMLKVMAPGF 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	148/305 (49%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	23/56 (41%)
cpm	NP_001017591.1	M14_CPM	17..309	CDD:199848	150/309 (49%)
cpm	NP_001017591.1	Peptidase_M14NE-CP-C_like	313..393	CDD:200604	23/56 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575177
Domainoid	1	1.000	297	1.000	Domainoid score	I1439
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35367
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2209
OMA	1	1.010	-	-		QHG46397
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	1	1.000	-	-		oto40234
orthoMCL	1	0.900	-	-		OOG6_109920
Panther	1	1.100	-	-	LDO	PTHR11532
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770