DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and Cpe

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_037260.2	Gene:	Cpe / 25669	RGDID:	2394	Length:	476	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	168/418 - (40%)
Similarity:	232/418 - (55%)	Gaps:	53/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EPGLP----EPRAYMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVV 112
            |||.|    ..|..:.....:.|.||.:.||...|.:...:...::.:|::|:|.:||:|.|:.:
  Rat    29 EPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIEL 93

  Fly   113 SSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDNTRIHILPTMN 176
            |.:|..|..|:|:.||:||:||||.||||:|:.|.||....|.. ::.:..|:.:|||||:|::|
  Rat    94 SDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQRGNETIVNLIHSTRIHIMPSLN 158

  Fly   177 PDGY--AVSKEGTC-DGGQGRYNARGFDLNRNFPDYFK---QNNKRG------------------ 217
            |||:  |.|:.|.. |...||.||:|.||||||||..:   .|.|.|
  Rat   159 PDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNLKKIVDQNS 223

  Fly   218 --QPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAPS 280
              .|||.:|..||..|.||||.:||||.|||:||||.|.:     |.....:.|
  Rat   224 KLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRS-----GTAHEYSSC----------- 272

  Fly   281 LTPDDDVFKHLSLVYARNHAKMS--RGVACK--SATPAFENGITNGAAWYPLTGGMQDYNYVWYG 341
              |||.:|:.|:..|:..:..||  ....|:  ....:|.:|.|||.|||.:.|||||:||:...
  Rat   273 --PDDAIFQSLARAYSSFNPVMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSN 335

  Fly   342 CMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKIKGRDV 406
            |.|||:|:||.||||...||.|||||:.|||.:|.:.||||:|||.|..|.||..|:|.:.|.|.
  Rat   336 CFEITVELSCEKFPPEETLKSYWEDNKNSLINYLEQIHRGVKGFVRDLQGNPIANATISVDGIDH 400

  Fly   407 GFQTTKYGEFWRILLPGYYKVEVFAEGF 434
            ...:.|.|::||:|.||.||:...|.|:
  Rat   401 DVTSAKDGDYWRLLAPGNYKLTASAPGY 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	136/335 (41%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	24/54 (44%)
Cpe	NP_037260.2	M14_CPE	53..371	CDD:349437	136/335 (41%)
Cpe	NP_037260.2	Peptidase_M14NE-CP-C_like	375..449	CDD:200604	24/54 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920