DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and egl-21

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_501935.1	Gene:	egl-21 / 177940	WormBaseID:	WBGene00001189	Length:	472	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	172/491 - (35%)
Similarity:	249/491 - (50%)	Gaps:	96/491 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLLPSVLLLMLHLLLCDAKTVNPGDSMQMQHHQMTAEPGLPEPRAYMPDAQ--HLDFVYHDHEE 77
            :||:.::|.:..|..|                       |......:..||:  |    ||:..:
Worm     8 VLLVAALLAVTAHAFL-----------------------GFGSGSTHKDDAEWGH----YHNQAQ 45

  Fly    78 LTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREM 142
            |...|...:.:.|.:|.||.||:|::||.|.|:..|::|.||:..||:||.:||:|||||:|||:
Worm    46 LEAKLGEINEKCPEITTLYEIGQSVEGRPLVVIQFSTTPGEHIPTKPEVKLIGNMHGNEPIGREL 110

  Fly   143 LLHLIQYFVT-SYNTDQYVKWLLDNTRIHILPTMNPDGYAVSKEGTCDGGQ-----GRYNARGFD 201
            ||...:.... :.|.|:.:..||::|.|||||:|||||:.::. || :..|     ||.|..|.|
Worm   111 LLRFAETLCNGAINNDKEIVQLLNSTSIHILPSMNPDGFELAL-GT-EPAQRQWLTGRSNINGVD 173

  Fly   202 LNRNFPD---------------------YFKQNNKRGQPETDSVKDWISKIQFVLSGSLHGGALV 245
            |||:|||                     .|:.|..| ||||.:|..|...:.||||.:.|.|.||
Worm   174 LNRDFPDLDSIFYELQKIGVPKFDHLLSLFEDNVDR-QPETIAVGQWTLSLPFVLSANFHEGDLV 237

  Fly   246 ASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRG--VAC 308
            |:||:|...:....|            ..|||    :|||..|:.|:..||.|||.||:.  ..|
Worm   238 ANYPFDAAIDENSQK------------TAYSA----SPDDGTFRWLAKSYADNHAHMSKNDHAPC 286

  Fly   309 KSATP---AFENGITNGAAWYPLTGGMQDYNYVWYGCMEITLEISCCKFPPAYELKKYWEDNQLS 370
            ...:.   |.:.||||||.||.:.|||||:||:....||||||:||.|.|...:|.::|||||.|
Worm   287 DGTSQDAFARQGGITNGAKWYSVAGGMQDFNYLATNAMEITLELSCEKMPEGSQLPRFWEDNQKS 351

  Fly   371 LIKFLAEAHRGVQGFVFDP-AGMPIERASIKIKGRDVGFQTT---------KYGEFWRILLPGYY 425
            :.:::.::|.||:|.|.|. .|.||:||.:.|:.   |.:|.         ..|:|:|:|..|.|
Worm   352 IFEYVWKSHSGVKGMVVDAMTGEPIKRAVVWIRN---GTETVPVKHPVTTWSEGDFYRVLPAGKY 413

  Fly   426 KVEVFAEGFAPREVEFVI---VEQHPTLLNVTLQPS 458
            ::.|.|||:........:   |.....::|..|.|:
Worm   414 EIIVAAEGYDIAAKNVTVENKVRDSALVVNFALSPA 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	135/336 (40%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	25/86 (29%)
egl-21	NP_501935.1	M14_CP_N-E_like	40..358	CDD:199842	135/336 (40%)
egl-21	NP_501935.1	Peptidase_M14NE-CP-C_like	362..446	CDD:200604	25/86 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3014
OMA	1	1.010	-	-		QHG46397
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.810