DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and CPN1

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001299.1	Gene:	CPN1 / 1369	HGNCID:	2312	Length:	458	Species:	Homo sapiens

Alignment Length:	508	Identity:	187/508 - (36%)
Similarity:	267/508 - (52%)	Gaps:	89/508 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LPSVLLLMLHLLLCDAKTVNPGDSMQMQHHQMTAEPGLPEPRAYMPDAQHLDFVYHDHEELTRFL 82
            :..:|.:.|||||. .|.|.|                             :.|.:|.:::|.|.|
Human     1 MSDLLSVFLHLLLL-FKLVAP-----------------------------VTFRHHRYDDLVRTL 35

  Fly    83 RATSARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLI 147
            .......|.:|.:||||:|::||.|:|:..|..|..|...:|:||||||:||||.:|||::|.|.
Human    36 YKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLS 100

  Fly   148 QYFVTSY-NTDQYVKWLLDNTRIHILPTMNPDGYAV-SKEGTCDGGQ--GRYNARGFDLNRNFPD 208
            ::....: |.:|.:..|:.:|||||||:||||||.| :.:|....|.  ||.||.|.||||||||
Human   101 EFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPD 165

  Fly   209 ---YFKQNNKRG----------------QPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTP 254
               |...|.|.|                :|||.:|..|:....||||.:|||||:||:||||.:.
Human   166 LNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSF 230

  Fly   255 NSRLLKGICRSSALCAMFQTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFENGI 319
            ..| ::|:.|:            |.:.||||.:|:.|:.||:..|..|.:|..|..   .|.:||
Human   231 EHR-VRGVRRT------------ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGD---YFPDGI 279

  Fly   320 TNGAAWYPLTGGMQDYNYVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQG 384
            ||||:||.|:.||||:||:...|.|||||:||.||||..||::.|..|:.:||:||.:.|:|::|
Human   280 TNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKG 344

  Fly   385 FVFDPAGMPIERASIKIKGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPREVEFVIVEQHPT 449
            .|.|.....:..|.|.:.|.:....:..:|:::|:||||.|.|...|.|:.|..|...:....||
Human   345 MVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPT 409

  Fly   450 LLNVTLQPSKRLEGIGPMGPGGVPVGGVVGPGGLYRPIPSPQH-YRPPVPPYA 501
            |:|..|:.|  :..:.|:                 |..||.:| .|..|.|.|
Human   410 LVNFHLKRS--IPQVSPV-----------------RRAPSRRHGVRAKVQPQA 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	142/327 (43%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	23/73 (32%)
CPN1	NP_001299.1	Catalytic	21..340		143/334 (43%)
		M14_CPN	25..337	CDD:199846	142/327 (43%)
		Peptidase_M14NE-CP-C_like	341..415	CDD:200604	23/73 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..458		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850