DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and CPXM2

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_937791.2	Gene:	CPXM2 / 119587	HGNCID:	26977	Length:	756	Species:	Homo sapiens

Alignment Length:	419	Identity:	150/419 - (35%)
Similarity:	223/419 - (53%)	Gaps:	56/419 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPEPRAY------MPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVS 113
            ||:|..|      |.....|||.:|:::|:.:.::..:...||:|.:|:||||.||..|:.:.:|
Human   295 LPDPNNYYHRRNEMTTTDDLDFKHHNYKEMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEIS 359

  Fly   114 SSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSY-NTDQYVKWLLDNTRIHILPTMNP 177
            ..|.||.||:|:..|:...||||.:|||:||.|:|:....| ..:..:..|::.||||:||::||
Human   360 DHPGEHEVGEPEFHYIAGAHGNEVLGRELLLLLVQFVCQEYLARNARIVHLVEETRIHVLPSLNP 424

  Fly   178 DGYAVSKEGTCD-GG--QGRYNARGFDLNRNFPD---------------------------YFKQ 212
            |||..:.||..: ||  .||:...|.|:|.||||                           :|..
Human   425 DGYEKAYEGGSELGGWSLGRWTHDGIDINNNFPDLNTLLWEAEDRQNVPRKVPNHYIAIPEWFLS 489

  Fly   213 NNKRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSA 277
            .|.....||.:|..|:.||.|||.|:|.||.||.:||||          :.||.     ::|...
Human   490 ENATVAAETRAVIAWMEKIPFVLGGNLQGGELVVAYPYD----------LVRSP-----WKTQEH 539

  Fly   278 APSLTPDDDVFKHLSLVYARNHAKM--SRGVACKSATPAFENGITNGAAWYPLTGGMQDYNYVWY 340
            .|  ||||.||:.|:..||..|..|  :|...|.:.....|.|..|||:|:.:.|.:.|::|:..
Human   540 TP--TPDDHVFRWLAYSYASTHRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHT 602

  Fly   341 GCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKIKGRD 405
            .|.|:::.:.|.|:|...:|.:.||:|:.|||.|:.:.|||::|.|.|..|..|..|.|.::|.:
Human   603 NCFELSIYVGCDKYPHESQLPEEWENNRESLIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGIN 667

  Fly   406 VGFQTTKYGEFWRILLPGYYKVEVFAEGF 434
            ...:|...|::||:|.||.|.|...||||
Human   668 HDIRTANDGDYWRLLNPGEYVVTAKAEGF 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	118/337 (35%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	22/54 (41%)
CPXM2	NP_937791.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..131
		FA58C	137..292	CDD:238014
		FA58C	138..293	CDD:214572
		M14_CPX_like	314..639	CDD:199851	121/341 (35%)
		Peptidase_M14NE-CP-C_like	643..718	CDD:200604	22/54 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820