Protein Alignment CG4678 and Aebp1

DIOPT Version :9

• Sequence 1: NP_001138211.1
• Gene: CG4678 / 32652
• FlyBaseID: FBgn0030778
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001278786.1
• Gene: Aebp1 / 11568
• MGIID: 1197012
• Length: 1129
• Species: Mus musculus
• Alignment Length: 502
• Identity: 155/502 - (30%)
• Similarity: 251/502 - (50%)
• Gaps: 73/502 - (14%)

  Fly    22 LLLMLHLLLCDAKTVNPGDSMQMQHHQMTAEPGLPEPRAYMPDAQHLDFVYHDHEELTRFLRATS 86
            |.:.|.:|.|   .|.|..|...|:..:|.:              .|||.:|.::::.:.::|.:
Mouse   523 LCMRLEVLGC---PVTPVYSYYAQNEVVTTD--------------SLDFRHHSYKDMRQLMKAVN 570

  Fly    87 ARYPNLTALYSIGKSIQGRDLWVMVVSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFV 151
            ...|.:|..||:|||.:|..::.|.:|.:|.:|.:|:|:.:|...|||||.:|||:||.|:||..
Mouse   571 EECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLC 635

  Fly   152 TSY-NTDQYVKWLLDNTRIHILPTMNPDGYAVSKEGTCDGGQ---GRYNARGFDLNRNFPD---- 208
            ..| :.:..|:.|:.:||||::|::|||||.|:.:...:.|.   |.:...|||:..:|||
Mouse   636 QEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSV 700

  Fly   209 -----------YFKQNNKRGQP------------ETDSVKDWISKIQFVLSGSLHGGALVASYPY 250
                       |...||....|            |..::..|:.|..|||..:|:||..:.||||
Mouse   701 LWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPY 765

  Fly   251 D--NTPNSRLLKGICRSSALCAMFQTYSAAPSLTPDDDVFKHLSLVYARNHAKMS---RGVACKS 310
            |  .||:...|.....::|........|.|.. |||..:|:.|::.:|..|..|:   || .|::
Mouse   766 DMARTPSQEQLLAEALAAARGEDDDGVSEAQE-TPDHAIFRWLAISFASAHLTMTEPYRG-GCQA 828

  Fly   311 ATPAFENGITNGAAWYPLTGGMQDYNYVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFL 375
            .......||.|||.|.|.:|...|::|:...|:|:::.:.|.|||...||.:.||:|:.:|:.|:
Mouse   829 QDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFM 893

  Fly   376 AEAHRGVQGFVFDPAGMPIERASIKIKGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGF------ 434
            .:.|||::|.|.|..|:||..|:|.:.|.:.|.:|...|::||||.||.|:|...|||:
Mouse   894 EQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKI 958

  Fly   435 -------APREVEFVIVEQHPTLLNVTL-----QPSKRLEGIGPMGP 469
                   ...:..|::...:...:...|     :|..|::...||.|
Mouse   959 CNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTP 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	110/340 (32%)
		Peptidase_M14NE-CP-C_like	381..455	CDD:200604	25/86 (29%)
Aebp1	NP_001278786.1	FA58C	376..532	CDD:214572	3/8 (38%)
		FA58C	378..531	CDD:238014	2/7 (29%)
		Required for DNA-binding and interaction with NFKBIA. /evidence=ECO:0000269|PubMed:17202411	382..547		8/26 (31%)
		Interaction with MAPK1 and MAPK3. /evidence=ECO:0000269|PubMed:11152475	413..616		29/109 (27%)
		Interaction with PTEN. /evidence=ECO:0000269|PubMed:17299101	547..977		141/445 (32%)
		M14_CPX_like	552..895	CDD:199851	113/344 (33%)
		Peptidase_M14NE-CP-C_like	899..974	CDD:200604	25/74 (34%)
		Required for transcriptional repression	933..1129		18/73 (25%)
		Interaction with MAPK1 and MAPK3. /evidence=ECO:0000269|PubMed:11152475	998..1129		3/8 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820