DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4678 and ebf4

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_004912820.1	Gene:	ebf4 / 100492234	XenbaseID:	XB-GENE-6030626	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	117/584 - (20%)
Similarity:	185/584 - (31%)	Gaps:	183/584 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DSMQMQHHQMTAEP---GLPEPRAYMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIG-- 99
            :|:|.....|..||   |:...|.:|..|..||                    .|..|...:|
Frog     6 ESIQRSGTSMKEEPLSGGMNAVRTWMQGAGVLD--------------------ANTAAQSGVGLA 50

  Fly   100 ---------KSIQGRDLWVMVVSSSPYEHMVGKP----DVKYVGNIHGNEPVGREMLLHLIQY-- 149
                     .:::..:.:..|::.  |:.. |:|    ...:||.:..::....|...:.|.|
Frog    51 RAHFEKQPPSNLRKSNFFHFVLAL--YDRQ-GQPVEIERTAFVGFVEKDKETSSEKTNNGIHYRL 112

  Fly   150 ---FVTSYNTDQ--YVKWLLDNTRIHIL---PTMNPD------GYAVSKEGTCDGGQ-GRYNARG 199
               :.....|:|  ||:.:...|:..|:   ...||:      .:.:.....||... |..|...
Frog   113 QLLYSNGIRTEQDFYVRLIDSMTKQPIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETP 177

  Fly   200 FD---LNRNFPDYFKQNNKRGQPETDSVKDWISKIQFVLSGSLH--GGALVAS---YPYDNTPNS 256
            .|   ::|.|..:|.:.|:.......:.:| :.:.|.|:|.:::  |..|..|   :.::|:.:.
Frog   178 SDPVIIDRFFLKFFLKCNQNCLKNAGNPRD-MRRFQVVVSTTINVDGHVLAVSDNMFVHNNSKHG 241

  Fly   257 RLLKGICRSSALCAMFQTYSAAPSLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPAFE----- 316
            |                   .|..|.|.|....:|      .||          |||..:
Frog   242 R-------------------RARRLDPSDGTPSYL------EHA----------ATPCIKAISPS 271

  Fly   317 NGITNGAAWYPLTG-----GMQ---DYNYVWY------------------GCMEITLEISC---C 352
            .|.|.|.|...:.|     |:|   ....||.                  |.:|:||....   |
Frog   272 EGWTTGGATVIVIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFC 336

  Fly   353 KFPPA----YELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIKIKGRDVGFQTTKY 413
            |..|.    ..|.:...|.....::.:...|.|      ||..:|.|    .|..|........|
Frog   337 KGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPG------DPERLPKE----VILKRAADLVEALY 391

  Fly   414 GEFWRILLPGYYKVEVFAEGFAPREVEFVIVEQH---PTLLNVTLQPSKRLEGIGPMG----PGG 471
            |      :|...:..:........|..:.:...|   |.|.|.::.|       |.||    .|.
Frog   392 G------MPHNNQEIILKRAADIAEALYSVPRNHSQLPALTNSSVHP-------GMMGVNSFSGQ 443

  Fly   472 VPVGGVVGPG-----GLYRPIP--SPQHYRPPVPPYAGAASSDSGIFSTISNGL-NSLYSNIFG 527
            :.| .|..|.     |..|...  ||..|.|...|.....||    .:|..||. |:..||:.|
Frog   444 LAV-NVSEPSQVTNQGFSRNTSSVSPHSYAPSTTPQQTNYSS----VTTSMNGYGNTAMSNLAG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	66/382 (17%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	15/76 (20%)
ebf4	XP_004912820.1	COE1_DBD	23..247	CDD:293031	45/266 (17%)
		IPT_COE	263..347	CDD:238580	17/83 (20%)
		COE1_HLH	348..391	CDD:293032	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11366
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000