DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and cpxm1b

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_009289577.1	Gene:	cpxm1b / 100330305	ZFINID:	ZDB-GENE-141212-305	Length:	959	Species:	Danio rerio

Alignment Length:	470	Identity:	163/470 - (34%)
Similarity:	244/470 - (51%)	Gaps:	78/470 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPEPRAYMP------DAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMVVS 113
            ||:|....|      ....|||.:|:::|:.:.:::.:...|::|.:||||||..|..|:||.:|
Zfish   481 LPDPNNIYPWQSEDGSQDKLDFRHHNYKEMRKLMKSVNEMCPDITRIYSIGKSYMGLKLYVMEIS 545

  Fly   114 SSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDNTRIHILPTMNP 177
            .:|.:|.:|:|:.:||..:||||.:|||:.|:|:|:....|.. :|.:..|:..||||:||.|||
Zfish   546 DNPGKHELGEPEFRYVAGMHGNEVLGRELQLNLMQFICQEYRRGNQRILHLVKETRIHLLPAMNP 610

  Fly   178 DGYAVS-KEGTCDGG--QGRYNARGFDLNRNF---------------------------PDYFKQ 212
            |||.:: |:|:...|  .|||:..|.|:|.||                           |:.:..
Zfish   611 DGYEMAYKKGSELAGWALGRYSYEGIDMNHNFADLNTVMWDAIELQTDKSKLINHYFPIPEQYTS 675

  Fly   213 NNKRGQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSA 277
            .:....|||.:|..|:..|.||||.:||||.||.:||:|                     .|...
Zfish   676 EDAWVAPETRAVISWMQTIPFVLSANLHGGELVVTYPFD---------------------MTRDW 719

  Fly   278 AP---SLTPDDDVFKHLSLVYARNHAKMSR--GVACKSATPAFENGITNGAAWYPLTGGMQDYNY 337
            ||   :.|.||..|:.|:.|||..:..||.  ...|.:......|.|.|||.|:.:.|.|.|::|
Zfish   720 APREQTPTADDSFFRWLATVYASTNHVMSNPDRRPCHNEDFLRHNNIINGANWHTVPGSMNDFSY 784

  Fly   338 VWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFD---PAGMPIERASI 399
            :...|.|:|:|:||.|||.|.||...|::|:.||:.::.:.|||::|.:.|   .||  |..|.|
Zfish   785 LHTNCFEVTVELSCDKFPHASELPTEWQNNKESLLVYMEQVHRGIKGVIRDKDTEAG--IADAII 847

  Fly   400 KIKGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPR----EVEFVIVEQHPTL--LNVTLQPS 458
            |:...|...::...|:|||:|.||.|.:.|.|||:.|.    .||:   |.:|||  ..:|..|.
Zfish   848 KVDDIDHHIRSAADGDFWRLLNPGDYDITVTAEGYFPASRSCRVEY---EHYPTLCDFRLTKTPK 909

  Fly   459 KRLEGIGPMGPGGVP 473
            :||..|...| |.:|
Zfish   910 QRLREILAKG-GKIP 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	117/340 (34%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	29/82 (35%)
cpxm1b	XP_009289577.1	CAF-1_p60_C	94..294	CDD:292150
		DUF4663	<109..219	CDD:292296
		Sec_Non_Glob	164..>297	CDD:275213
		FA58C	321..479	CDD:214572
		FA58C	323..478	CDD:238014
		M14_CPX_like	500..824	CDD:199851	120/344 (35%)
		Peptidase_M14NE-CP-C_like	828..904	CDD:200604	29/80 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	1	1.000	-	-		FOG0000769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920