DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4678 and cpz

DIOPT Version :9

Sequence 1:	NP_001138211.1	Gene:	CG4678 / 32652	FlyBaseID:	FBgn0030778	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_012812537.1	Gene:	cpz / 100170588	XenbaseID:	XB-GENE-994183	Length:	662	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	173/530 - (32%)
Similarity:	253/530 - (47%)	Gaps:	126/530 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QMTAEPGLPE-PRAYMPDAQHLDFVYHDHEELTRFLRATSARYPNLTALYSIGKSIQGRDLWVMV 111
            ::|.|..|.| |..:      :.|::|.:.::.|.|:.|:||...::..||||:|.:|:||..:.
Frog   173 EITPEDLLTETPSTF------IQFIHHSYSDMVRVLKKTAARCSQISKTYSIGRSYEGKDLLAIE 231

  Fly   112 VSSSPYEHMVGKPDVKYVGNIHGNEPVGREMLLHLIQYFVTSYNT-DQYVKWLLDNTRIHILPTM 175
            .|:.|.:|....|:.:|:||:||||..|||:|::|.|:..:.|.. :..::.|::.||||:||:|
Frog   232 FSAQPGQHKALTPEFRYIGNMHGNEVAGRELLIYLAQFLCSEYLLGNSRIQTLINTTRIHLLPSM 296

  Fly   176 NPDGYA-VSKEGTCDGG--QGRYNARGFDLNRNFPDYFKQNNK---------------------R 216
            |||||. .::||....|  .||.||:..||||||||...:.:|                     :
Frog   297 NPDGYEHAAEEGAGYNGWTNGRLNAQNIDLNRNFPDLTSEVHKIIRMPMARLDHMPIPESYWDGK 361

  Fly   217 GQPETDSVKDWISKIQFVLSGSLHGGALVASYPYDNTPNSRLLKGICRSSALCAMFQTYSAAP-- 279
            ..||..:|..|:..|.||:|||||||.||.|||||                       :|..|
Frog   362 IAPEAKAVMKWMRSIPFVISGSLHGGDLVVSYPYD-----------------------FSRHPLE 403

  Fly   280 ----SLTPDDDVFKHLSLVYARNHAKMSRGVACKSATPA---FEN--GITNGAAWYPLTGGMQDY 335
                |.|||:.||:.|...|...|..||.    ||.:..   |.|  ||.|||.||..:|||.|:
Frog   404 EKMFSPTPDEKVFQMLVKTYVAAHPIMSD----KSTSRCGGNFNNKGGIINGAEWYSFSGGMADF 464

  Fly   336 NYVWYGCMEITLEISCCKFPPAYELKKYWEDNQLSLIKFLAEAHRGVQGFVFDPAGMPIERASIK 400
            :|:...|.|:|||:.|.|||...||...|::|:.:::..:...|||::|||.|..|.||::|.|.
Frog   465 SYLHTNCFELTLELGCEKFPTEDELYSIWQNNKEAMLSLIEMVHRGIKGFVKDEHGNPIKKARIS 529

  Fly   401 IKGRDVGFQTTKYGEFWRILLPGYYKVEVFAEGFAPREVEFVIVEQHPTLLNVTLQPSKRLEGIG 465
            :||......|.:.|:::|:|:||.|.|...|.|::            .....:|| |:|.|:
Frog   530 VKGIRHDITTGEDGDYFRLLIPGSYIVSAEAFGYS------------KVTKKITL-PAKMLK--- 578

  Fly   466 PMGPGGVPVGGV----------------VGPGGLYR---PI----PSPQHYRPPVPPYAGAASSD 507
                    .|.|                |.|..:|.   |:    |..||         |.|...
Frog   579 --------AGRVDFALQRVDVKNRKFHKVAPEDIYERFDPLDRFDPHAQH---------GVAEQS 626

  Fly   508 SGIFSTISNG 517
            .|...:..||
Frog   627 EGGEESSRNG 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4678	NP_001138211.1	M14_CP_N-E_like	72..377	CDD:199842	124/340 (36%)
CG4678	NP_001138211.1	Peptidase_M14NE-CP-C_like	381..455	CDD:200604	22/73 (30%)
cpz	XP_012812537.1	CRD_FZ	46..169	CDD:382974
		M14_CPZ	192..506	CDD:349439	124/340 (36%)
		Peptidase_M14NE-CP-C_like	510..586	CDD:200604	29/99 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920