DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4653 and PRSS1

DIOPT Version :9

Sequence 1:	NP_573150.2	Gene:	CG4653 / 32650	FlyBaseID:	FBgn0030776	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	267	Identity:	80/267 - (29%)
Similarity:	130/267 - (48%)	Gaps:	36/267 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SPVQSYSHSRLLLLVVIVTLGVVQSSRLP------------AEVGSQPHSISLRRNGVHVCGGAL 54
            |...|.:||..:..::|:|. |..:...|            .|..|.|:.:|| .:|.|.|||:|
Human   215 SSTTSQAHSTTMNPLLILTF-VAAALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSL 277

  Fly    55 IREKWILTAAHCVSLGGGQQSYPAKSYNVRVG--SIQRLTGG-QLVPLSKIIIHTNYSSSDAVGS 116
            |.|:|:::|.||         |.:: ..||:|  :|:.|.|. |.:..:|||.|..|.....  :
Human   278 INEQWVVSAGHC---------YKSR-IQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTL--N 330

  Fly   117 NDLALLELETSVVLNANTNPIDLATERPAAGSQIIFSGWGSSQVDGS-LSHVLQVATRQSLSASD 180
            ||:.|::|.:..|:||..:.|.|.|..||.|::.:.||||::...|: ....||......||.:.
Human   331 NDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 395

  Fly   181 CQTELYLQQ--EDLLCLSPVDEDFAGLCSGDAGAPASYNNQLVGIAAFFVSGCGSE-QPDGYVDV 242
            |:.. |..:  .::.|:..: |.....|.||:|.|...|.||.|:.: :..||..: :|..|..|
Human   396 CEAS-YPGKITSNMFCVGFL-EGGKDSCQGDSGGPVVCNGQLQGVVS-WGDGCAQKNKPGVYTKV 457

  Fly   243 TQHLEWI 249
            ..:::||
Human   458 YNYVKWI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4653	NP_573150.2	Tryp_SPc	30..252	CDD:238113	73/239 (31%)
CG4653	NP_573150.2	Tryp_SPc	30..249	CDD:214473	71/237 (30%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	70/231 (30%)
		Tryp_SPc	249..467	CDD:238113	72/232 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820