Protein Alignment CG4653 and KLK1

DIOPT Version :10

• Sequence 1: NP_573150.2
• Gene: CG4653 / 32650
• FlyBaseID: FBgn0030776
• Length: 254
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 73/273 - (26%)
• Similarity: 120/273 - (43%)
• Gaps: 54/273 - (19%)

  Fly    13 LLLVVIVTLG------VVQSSRL---PAEVGSQPHSISLRRNGVHVCGGALIREKWILTAAHCVS 68
            |:|.:.::||      .:||..:   ..|..|||...:|.......|||.|:..:|:||||||:|
Human     4 LVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCIS 68

  Fly    69 ------LGGG--------------QQSYPAKSYNVRVGSIQRLTGGQLVPLSKIIIHTNYSSSDA 113
                  ||..              .:|:|...:|                :|.:..||..:..|.
Human    69 DNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFN----------------MSLLENHTRQADEDY 117

  Fly   114 VGSNDLALLEL-ETSVVLNANTNPIDLATERPAAGSQIIFSGWGSSQVDG-SLSHVLQVATRQSL 176
              |:||.||.| |.:..:......::|.||.|..||..:.|||||.:.:. |....||....:.|
Human   118 --SHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL 180

  Fly   177 SASDCQTELYLQQ--EDLLCLSPVDEDFAGLCSGDAGAPASYNNQLVGIAAFFVSGCGS-EQPDG 238
            ...:|: :.::|:  :.:||:..: |.....|.||:|.|...:..|.|:.::....||: .:|..
Human   181 PNDECK-KAHVQKVTDFMLCVGHL-EGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSV 243

  Fly   239 YVDVTQHLEWINE 251
            .|.|..:::||.:
Human   244 AVRVLSYVKWIED 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4653	NP_573150.2	Tryp_SPc	30..252	CDD:238113	67/247 (27%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	67/252 (27%)