DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4653 and prss60.3

DIOPT Version :9

Sequence 1:	NP_573150.2	Gene:	CG4653 / 32650	FlyBaseID:	FBgn0030776	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_002662541.2	Gene:	prss60.3 / 335152	ZFINID:	ZDB-GENE-030131-7092	Length:	330	Species:	Danio rerio

Alignment Length:	249	Identity:	70/249 - (28%)
Similarity:	105/249 - (42%)	Gaps:	52/249 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AEVGSQPHSISLR--RNGVHVCGGALIREKWILTAAHCVS----------LGGGQQSYPAKSYNV 83
            |..||.|..:||.  :.|.|.|||:||..:|:||||||:|          ||...|.      .:
Zfish    42 ASPGSWPWQVSLHSPKYGGHFCGGSLISSEWVLTAAHCLSGVSETTLVVYLGRRTQQ------GI 100

  Fly    84 RVGSIQRLTGGQLVPLSKIIIHTNYSSSDAVGSNDLALLELETSVVLNANTNPIDLATERP--AA 146
            .:....|       .::|..:|::|:|:  ...||:|||.|.::|.......|:.||.:..  :|
Zfish   101 NIYETSR-------NVAKSFVHSSYNSN--TNDNDIALLRLSSAVTFTNYIRPVCLAAQNSVYSA 156

  Fly   147 GSQIIFSGWGSSQVDGSL--SHVLQVATRQSLSASDCQTEL--YLQQEDLLCLSPVDEDFAGL-- 205
            |:....:|||..|...:|  ..:||......::...|...|  .....:::|        |||
Zfish   157 GTSSWITGWGDIQAGVNLPAPGILQETMIPVVANDRCNALLGSGTVTNNMIC--------AGLTQ 213

  Fly   206 -----CSGDAGAPASYNNQLVGIAAFFVS---GCGS-EQPDGYVDVTQHLEWIN 250
                 |.||:|.|.......|.:.|...|   ||.. ..|..|..|:|:..||:
Zfish   214 GGKDTCQGDSGGPMVTRLCTVWVQAGITSWGYGCADPNSPGVYTRVSQYQSWIS 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4653	NP_573150.2	Tryp_SPc	30..252	CDD:238113	70/249 (28%)
CG4653	NP_573150.2	Tryp_SPc	30..249	CDD:214473	68/246 (28%)
prss60.3	XP_002662541.2	Tryp_SPc	36..269	CDD:238113	70/249 (28%)
prss60.3	XP_002662541.2	Somatomedin_B	294..328	CDD:321959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930