Protein Alignment HRAS and RAS1

DIOPT Version :10

• Sequence 1: NP_005334.1
• Gene: HRAS / 3265
• HGNCID: 5173
• Length: 189
• Species: Homo sapiens
• Sequence 2: NP_014744.1
• Gene: RAS1 / 854268
• SGDID: S000005627
• Length: 309
• Species: Saccharomyces cerevisiae
• Alignment Length: 173
• Identity: 105/173 - (60%)
• Similarity: 132/173 - (76%)
• Gaps: 3/173 - (1%)

Human     3 EYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAM 67
            |||:||||.|||||||||||.||::||||||||||||||||||||.:..:|||||||||||||||
Yeast    10 EYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAM 74

Human    68 RDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLA-ARTVESRQAQ 131
            |:||||||||||.|:::.:..||:::..|.:||:||||||.:|:|:||||.||. .|.|......
Yeast    75 REQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGL 139

Human   132 DLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQH--KLRKLN 172
            .||:....|::|||||....|::|||:|:|.:|..  |...:|
Yeast   140 RLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMN 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRAS	NP_005334.1	H_N_K_Ras_like	3..164	CDD:133338	102/161 (63%)
		Effector region	32..40		7/7 (100%)
		Hypervariable region	166..185		2/9 (22%)
RAS1	NP_014744.1	small_GTPase	9..172	CDD:197466	102/161 (63%)