Protein Alignment sphe and PRSS2

DIOPT Version :10

• Sequence 1: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Sequence 2: NP_001290343.1
• Gene: PRSS2 / 5645
• HGNCID: 9483
• Length: 261
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 69/259 - (26%)
• Similarity: 120/259 - (46%)
• Gaps: 19/259 - (7%)

  Fly     6 LVILGLIGLTAVGMCHAQGRIMGGEDADATATTFTASLRVDNAHVCGGSILSQTKILTTAHCVHR 70
            |:||..:............:|:||...:..:..:..||. ...|.||||::|:..:::..||...
Human     4 LLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLN-SGYHFCGGSLISEQWVVSAGHCYKS 67

  Fly    71 ------DGKLIDASRLACRVGSTN-QYAGG--KIVNVESVAVHPDYYN--LNNNLAVITLSSELT 124
                  .|:..:..|:..|:|..| :...|  :.:|...:..||.|.:  |:|::.:|.|||...
Human    68 AINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAV 132

  Fly   125 YTDRITAIPLVASGEALPAEGSEVIVAGWGRTSDGTNSY--KIRQISLKVAPEATCLDAYSDH-D 186
            ...|::||.|..   |.||.|:|.:::|||.|......|  :::.:...|..:|.|..:|... .
Human   133 INSRVSAISLPT---APPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT 194

  Fly   187 EQSFCLAH-ELKEGTCHGDGGGGAIYGNTLIGLTNFVVGACGSRYPDVFVRLSSYADWIQEQIA 249
            ...||:.. |..:.:|.||.||..:....|.|:.::..|......|.|:.::.:|.|||::.||
Human   195 NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIA 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	61/219 (28%)
PRSS2	NP_001290343.1	Tryp_SPc	24..256	CDD:238113	64/235 (27%)