Protein Alignment sphe and PLAT

DIOPT Version :10

• Sequence 1: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 62/264 - (23%)
• Similarity: 118/264 - (44%)
• Gaps: 49/264 - (18%)

  Fly    23 QGRIMGGEDADATATTFTASLRVDNAH------VCGGSILSQTKILTTAHCVHRDGKLIDASRLA 81
            |.||.||..||..:..:.|::...:..      :|||.::|...||:.|||..   :......|.
Human   308 QFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ---ERFPPHHLT 369

  Fly    82 CRVGSTNQYAGG---KIVNVESVAVHPDYYN--LNNNLAVITLSSELTYTDRITAIPLVASGEAL 141
            ..:|.|.:...|   :...||...||.::.:  .:|::|::.|.|:   :.|......|.....|
Human   370 VILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSD---SSRCAQESSVVRTVCL 431

  Fly   142 P------AEGSEVIVAGWGRTSDGTNSY--KIRQISLKVAPEATCLDAYSDH------DEQSFCL 192
            |      .:.:|..::|:|:....:..|  ::::..:::.|.:.|.   |.|      .:...|
Human   432 PPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCT---SQHLLNRTVTDNMLC- 492

  Fly   193 AHELKEG--------TCHGDGGGGAIYGN----TLIGLTNFVVGACGSR-YPDVFVRLSSYADWI 244
            |.:.:.|        .|.||.||..:..|    ||:|:.::.:| ||.: .|.|:.::::|.|||
Human   493 AGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLG-CGQKDVPGVYTKVTNYLDWI 556

  Fly   245 QEQI 248
            ::.:
Human   557 RDNM 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	54/242 (22%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	59/256 (23%)