Protein Alignment sphe and PRSS48

DIOPT Version :10

• Sequence 1: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Sequence 2: NP_001340540.1
• Gene: PRSS48 / 345062
• HGNCID: 24635
• Length: 346
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 70/268 - (26%)
• Similarity: 116/268 - (43%)
• Gaps: 36/268 - (13%)

  Fly     8 ILGLIGLTAVGMCHAQGRIMGGEDADATATTFTASLRVDNAHVCGGSILSQTKILTTAHCVHRDG 72
            :|.|:|::..|......|::||:||.|....:..||..|:..:||||::|:..|||.|||:....
Human    10 LLLLLGISVCGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTW 74

  Fly    73 KLIDASRLACRVGSTNQYAGGKIVN--VESVAVHPDYYNLNNNLAVITLSSELTYTDRITAI--P 133
            ....   ....:||.......|.|.  |..:.:||.|.:...::|::.|||::|:|..|..|  |
Human    75 TTFS---YTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTADVALLKLSSQVTFTSAILPICLP 136

  Fly   134 LVASGEALPAEGSEVIVAGWGR---TSDGTNSYKIRQISLKVAPEATCLDAYSD----------- 184
            .|....|:|   ....|.|||:   :||......:::..:.:.....|...|:.
Human   137 SVTKQLAIP---PFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPV 198

  Fly   185 HDEQSFCL--AHELKEGTCHGDGGG------GAIYGNTLIGLTNFVVGACGSRYPDVFVRLSSYA 241
            ..|...|.  ...:|: :|.||.||      ..::..|  |:.::.: .||...|.|:..:..|.
Human   199 IKEDKICAGDTQNMKD-SCKGDSGGPLSCHIDGVWIQT--GVVSWGL-ECGKSLPGVYTNVIYYQ 259

  Fly   242 DWIQEQIA 249
            .||...|:
Human   260 KWINATIS 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	59/230 (26%)
PRSS48	NP_001340540.1	Tryp_SPc	28..265	CDD:238113	64/246 (26%)