DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sphe and Prss53

DIOPT Version :9

Sequence 1:	NP_573148.2	Gene:	sphe / 32648	FlyBaseID:	FBgn0030774	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_001074737.1	Gene:	Prss53 / 330657	MGIID:	2652890	Length:	552	Species:	Mus musculus

Alignment Length:	298	Identity:	66/298 - (22%)
Similarity:	118/298 - (39%)	Gaps:	83/298 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QPRLVILGLI----GLTAVGMCHAQ----------GRIMGGEDADATATTFTASLRVDNAHVCGG 53
            :|.|:|:|.:    ||.|......|          |..:.||      ..:.||:|....|:|.|
Mouse     6 RPELLIVGAVVVIEGLQAAQRACGQRGPGPPEPQEGNTLPGE------WPWQASVRRQGVHICSG 64

  Fly    54 SILSQTKILTTAHCVHRDGKLIDASRLACRVGSTNQYA---GGKIVNVESVAVHPDY--YNLNNN 113
            |:::.|.:||.|||..:.. ..:.|..:..:||..|..   |.:.|.|.::.:...|  |:..::
Mouse    65 SLVADTWVLTAAHCFEKMA-TAELSSWSVVLGSLKQEGQSPGAEEVGVAALQLPKAYNHYSQGSD 128

  Fly   114 LAVITLSSELTYTDRITAIPLVASGEALPAE------GSEVIVAGWGR-TSDGTNSYKIRQISLK 171
            ||::    :||:       |.|.:...||..      |:.....||.: |||.:.:  :|.:.|:
Mouse   129 LALL----QLTH-------PTVQTTLCLPQPTYHFPFGASCWATGWDQNTSDVSRT--LRNLRLR 180

  Fly   172 VAPEATCLDAYSDHDEQSFCLAHEL---------------------KEGTCHGDGGGGAIY---- 211
            :....||           .||.:.|                     ::|.|.||.||..:.
Mouse   181 LISRPTC-----------NCLYNRLHQRLLSNPARPGMLCGGAQPGEQGPCQGDSGGPVMCREPD 234

  Fly   212 GNTL-IGLTNFVVGACGSRYPDVFVRLSSYADWIQEQI 248
            |:.: :|:.:|.........|.:...::.::.|:|..:
Mouse   235 GHWVQVGIISFTSKCAQEDTPVLLTDMAVHSSWLQAHV 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	54/242 (22%)
sphe	NP_573148.2	Tryp_SPc	42..244	CDD:214473	52/239 (22%)
Prss53	NP_001074737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..46		2/18 (11%)
		Tryp_SPc	45..271	CDD:238113	57/256 (22%)
		Tryp_SPc	311..522	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100