Protein Alignment sphe and GZMA

DIOPT Version :10

• Sequence 1: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Sequence 2: NP_006135.2
• Gene: GZMA / 3001
• HGNCID: 4708
• Length: 262
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 65/260 - (25%)
• Similarity: 118/260 - (45%)
• Gaps: 41/260 - (15%)

  Fly     7 VILGLIGLTAVGMCHAQGRIMGGEDADATATTFTASLRVDNAHVCGGSILSQTKILTTAHC-VHR 70
            |::.|: |....:|.   :|:||.:....:..:...|.:|...:|.|:::::..:||.||| :::
Human    14 VVVSLL-LIPEDVCE---KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNK 74

  Fly    71 DGKLIDASRLACRVGSTNQYAGGKIVNVESVAVHPDY--YNLNNNLAVITLSSELTYTDRITAIP 133
            ..::|..:....|...|.|     |:.|:....:|.|  .....:|.::.|..:......:|.:.
Human    75 RSQVILGAHSITREEPTKQ-----IMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILH 134

  Fly   134 LVASGEALPAEGSEVIVAGWGRTSDGTN-SYKIRQISLKVAPEATCLDAYSDHDEQSF------- 190
            |...|:.: ..|:...|||||||.:..: |..:|::::.:.....|    :|.:..:|
Human   135 LPKKGDDV-KPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVC----NDRNHYNFNPVIGMN 194

  Fly   191 --CLAHELKEG--TCHGDGGG-----GAIYGNTLIGLTNFVVGACGS-RYPDVFVRLS-SYADWI 244
              | |..|:.|  :|:||.|.     |...|.|..||.|    .||. |.|.|::.|| .:.:||
Human   195 MVC-AGSLRGGRDSCNGDSGSPLLCEGVFRGVTSFGLEN----KCGDPRGPGVYILLSKKHLNWI 254

  Fly   245  244
            Human   255  254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	58/225 (26%)
GZMA	NP_006135.2	Tryp_SPc	29..254	CDD:238113	59/239 (25%)