Protein Alignment sphe and KLK5

DIOPT Version :10

• Sequence 1: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Sequence 2: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Alignment Length: 236
• Identity: 67/236 - (28%)
• Similarity: 108/236 - (45%)
• Gaps: 18/236 - (7%)

  Fly    22 AQGRIMGGEDADATATTFTASLRV-DNAHVCGGSILSQTKILTTAHCVHRDGKLIDASRLACRVG 85
            :..||:.|.|.|.....:.|:|.: .|...||..::....:||.|||    .|.:...||. ...
Human    63 SSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHC----RKKVFRVRLG-HYS 122

  Fly    86 STNQYAGGK--IVNVESVAVHPDYYN--LNNNLAVITLSSELTYTDRITAIPLVASGEALPAEGS 146
            .:..|..|:  ...|:|:. ||.|.:  .:|:|.:|.|:..:..|..:.  |:..|... |:.|:
Human   123 LSPVYESGQQMFQGVKSIP-HPGYSHPGHSNDLMLIKLNRRIRPTKDVR--PINVSSHC-PSAGT 183

  Fly   147 EVIVAGWGRT-SDGTNSYKIRQ-ISLKVAPEATCLDAYSDH-DEQSFCLAHELKEGTCHGDGGGG 208
            :.:|:|||.| |...:..|:.| :::.|..:..|.|||... |:..||...:....:|.||.||.
Human   184 KCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGP 248

  Fly   209 AIYGNTLIGLTNFVVGACG-SRYPDVFVRLSSYADWIQEQI 248
            .:...:|.||.::....|. ...|.|:..|..:..||||.|
Human   249 VVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETI 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	59/213 (28%)
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		1/4 (25%)
		Tryp_SPc	66..285	CDD:214473	62/227 (27%)