DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sphe and PRSS36

DIOPT Version :9

Sequence 1:	NP_573148.2	Gene:	sphe / 32648	FlyBaseID:	FBgn0030774	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	254	Identity:	67/254 - (26%)
Similarity:	113/254 - (44%)	Gaps:	25/254 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GMCHAQGRIMGGEDADATATTFTASLRVDNAHVCGGSILSQTKILTTAHCVHRDGKLIDASRLAC 82
            |......||:||.:|......:..||.....|:||||:::.:.:|:.|||...:|.|..|:..:.
Human    39 GRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103

  Fly    83 RVGSTNQ---YAGGKIVNVESVAVHPDY--YNLNNNLAVITLSSELTYTDRITAIPLVASGEALP 142
            .:|..:|   ..|.....|.::.|..:|  ..|..:||::.|:|..:....:..:.|..:....
Human   104 LLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRF- 167

  Fly   143 AEGSEVIVAGWGRTSDGTN---SYKIRQISLKVAPEATCLDAYSDHDEQS---------FCLAH- 194
            ..|:.....|||...:...   .:.::::.|::..||||...||.....:         .|..:
Human   168 VHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYP 232

  Fly   195 ELKEGTCHGDGGGGAIY---GNTL-IGLTNFVVGACGSR-YPDVFVRLSSYADWIQEQI 248
            |.:..||.||.||..:.   |... .|:|:|..| ||.| .|.||..:::|..||:||:
Human   233 EGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFG-CGRRNRPGVFTAVATYEAWIREQV 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	59/227 (26%)
sphe	NP_573148.2	Tryp_SPc	42..244	CDD:214473	57/224 (25%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	62/241 (26%)
		Tryp_SPc	47..289	CDD:238113	63/243 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100