DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9676 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_728008.1	Gene:	CG9676 / 32647	FlyBaseID:	FBgn0030773	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	252	Identity:	83/252 - (32%)
Similarity:	126/252 - (50%)	Gaps:	23/252 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CAAG------VLAQNDSVVEPRIVGGTKAREGQFPHQISLRRRGSHTCGGSIISKDYVVTAAHCV 70
            |.:|      .||...|:..||:||..:|....:|.|:|::....|.|||||:...:|:|||||.
Human   183 CLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF 247

  Fly    71 KQGNNVAPANELEIQAGSLLLSSGGVRVPVATVTV---HPNYNSNGHDVAVLRLRNSLTFNSNIA 132
            ::..:|.   ..:::|||..|.| ...:.||.:.:   :|.|..: :|:|:::|:..|||:..:.
Human   248 RKHTDVF---NWKVRAGSDKLGS-FPSLAVAKIIIIEFNPMYPKD-NDIALMKLQFPLTFSGTVR 307

  Fly   133 AIKLATEDPP-NDAT-VDISGWGAISQR-GPISNSLLYVQVKALSRESC--QKTYLRQLPETTMC 192
            .|.|...|.. ..|| :.|.|||...|. |.:|:.||...|:.:....|  ...|..::.|..||
Human   308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMC 372

  Fly   193 LLHPK-DKGACYGDSGGPATYQG---KLVGLASFVIGGCGRAAPDGYERVSKLRNWI 245
            ...|: ....|.||||||..||.   .:||:.|:..|..|.:.|..|.:||...|||
Human   373 AGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9676	NP_728008.1	Tryp_SPc	27..245	CDD:214473	75/229 (33%)
CG9676	NP_728008.1	Tryp_SPc	28..248	CDD:238113	76/230 (33%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	4/13 (31%)
		Tryp_SPc	204..429	CDD:214473	75/229 (33%)
		Tryp_SPc	205..432	CDD:238113	76/230 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910