DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9676 and TMPRSS11A

DIOPT Version :9

Sequence 1:	NP_728008.1	Gene:	CG9676 / 32647	FlyBaseID:	FBgn0030773	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_872412.3	Gene:	TMPRSS11A / 339967	HGNCID:	27954	Length:	421	Species:	Homo sapiens

Alignment Length:	257	Identity:	77/257 - (29%)
Similarity:	123/257 - (47%)	Gaps:	30/257 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CAAGVLAQNDSVVEPRIVGGTKAREGQFPHQISLRRRGSHTCGGSIISKDYVVTAAHCVKQGNNV 76
            |...|:..|.:    ||..|..|.:..:|.|.||:....|.||.::||..::||||||.::..|
Human   178 CGKRVVPLNVN----RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKN- 237

  Fly    77 APANELEIQAGSLL---LSSGGVRVPVATVTVHPNYNS--NGHDVAVLRLRNSLTFNSNIAAIKL 136
              .::..:..|:.:   |....||    ...:|..|.|  ..:|:||:::.:.:||:.:|..|.|
Human   238 --PHQWTVSFGTKINPPLMKRNVR----RFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICL 296

  Fly   137 ---ATEDPPNDATVDISGWGAISQRGPISNSLLYVQVKALSRESCQ--KTYLRQLPETTMCLLHP 196
               :....|| .||.|:|:||:...|...|.|...:||.:|.:.|:  :.|...:.....|..:.
Human   297 PEASASFQPN-LTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM 360

  Fly   197 KD-KGACYGDSGGPATYQG-----KLVGLASFVIGGCG-RAAPDGYERVSKLRNWIAEKASL 251
            :. ..||.||||||...:.     .|:|:.|:. ..|| :..|..|.:|:..|||||.|..:
Human   361 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWG-DNCGQKDKPGVYTQVTYYRNWIASKTGI 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9676	NP_728008.1	Tryp_SPc	27..245	CDD:214473	70/234 (30%)
CG9676	NP_728008.1	Tryp_SPc	28..248	CDD:238113	72/236 (31%)
TMPRSS11A	NP_872412.3	SEA	49..147	CDD:279699
		Tryp_SPc	189..415	CDD:214473	70/234 (30%)
		Tryp_SPc	190..418	CDD:238113	72/236 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910