DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9676 and HPN

DIOPT Version :9

Sequence 1:	NP_728008.1	Gene:	CG9676 / 32647	FlyBaseID:	FBgn0030773	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001362370.1	Gene:	HPN / 3249	HGNCID:	5155	Length:	417	Species:	Homo sapiens

Alignment Length:	245	Identity:	80/245 - (32%)
Similarity:	117/245 - (47%)	Gaps:	32/245 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RIVGGTKAREGQFPHQISLRRRGSHTCGGSIISKDYVVTAAHCVKQGNNVAPANELEIQAGSLLL 91
            |||||.....|::|.|:|||..|:|.||||::|.|:|:|||||..:.|.|  .:...:.||::..
Human   162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV--LSRWRVFAGAVAQ 224

  Fly    92 SS-GGVRVPVATVTVH--------PNYNSNGHDVAVLRLRNSLTFNSNIAAIKLATEDPPNDATV 147
            :| .|:::.|..|..|        ||...|.:|:|::.|.:.|.....|..:.|..   ...|.|
Human   225 ASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPA---AGQALV 286

  Fly   148 D-----ISGWGAISQRGPISNSLLYVQVKALSRESCQKT--YLRQLPETTMCLLHPKDK-GACYG 204
            |     ::|||.....|..:..|...:|..:|.:.|...  |..|:.....|..:|:.. .||.|
Human   287 DGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQG 351

  Fly   205 DSGGP--------ATYQGKLVGLASFVIGGCGRAAPDG-YERVSKLRNWI 245
            |||||        .|.:.:|.|:.|:.. ||..|...| |.:||..|.||
Human   352 DSGGPFVCEDSISRTPRWRLCGIVSWGT-GCALAQKPGVYTKVSDFREWI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9676	NP_728008.1	Tryp_SPc	27..245	CDD:214473	78/243 (32%)
CG9676	NP_728008.1	Tryp_SPc	28..248	CDD:238113	79/244 (32%)
HPN	NP_001362370.1	Hepsin-SRCR	51..159	CDD:401275
HPN	NP_001362370.1	Tryp_SPc	163..400	CDD:238113	77/242 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910