DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin14

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_083102.1	Gene:	Septin14 / 74222	MGIID:	1921472	Length:	429	Species:	Mus musculus

Alignment Length:	425	Identity:	142/425 - (33%)
Similarity:	221/425 - (52%)	Gaps:	69/425 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GSSSSGIEAVKCRPPIYPKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKS 99
            ||.....|.::|...:             .:.||..||.|:..||:::||.|.::.|||:|:||:
Mouse    14 GSEDPQKENIRCLSTL-------------GHFGFECLPTQLVNKSIQKGFSFNILCVGETGIGKT 65

  Fly   100 TLINSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWR 164
            ||||:||..:| |..:..:...::..|.    ||.::.||.:.||||||.|.|:||.||.|.|::
Mouse    66 TLINTLFNTNL-KETKSSHFYSKVGLTV----KTYELLERNIPLRLTVVKTVGYGDQINKEASYQ 125

  Fly   165 VCTQYIDEQFRQYFTDESGLNR--RNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVL 227
            ....|:|.||..|..:|..:.|  .:..|:|:|.||||:.|.||||:.:||..::.:.|:|||:.
Mouse   126 PVVDYLDAQFEAYLQEELKIKRSLADYHDSRIHVCLYFITPTGHSLKSLDLLTMKSIDRRVNIIP 190

  Fly   228 VIGKADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASI------PFA 286
            :|.|||.|:|.::::.|..|:.:|..|.||:|||            |.|.|..|.:      |||
Mouse   191 LIAKADSLSKNDLQRFKNNIMSELNSNGIQIYQF------------QVDDEASAQVNSSGLLPFA 243

  Fly   287 VVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQ 351
            ||||...::|..:.||||.|||||:.||:..|.||:|||..|:||:|:||||.|...|||.:|:.
Mouse   244 VVGSMEEVKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDLLLSTNMEDLKDQTHTQHYECYRSN 308

  Fly   352 CISQIS-------------------------QHALRERGKLKRDSISSTNGFDAAISETDRLLLQ 391
            .:.::.                         ....:|..:||:..:......:....:.::.|..
Mouse   309 RLQKLGFSDTGPDNRPVSFQEMYEAKRREFHNQCQKEEEELKQTFMQRVKEKELTFKDAEKELQD 373

  Fly   392 KDEEIRRMQDMLTQMQEKLKQTHLMEMKKNDSVID 426
            |.|.::|:|      ||::.:......|..:.:||
Mouse   374 KFEHLKRIQ------QEEILKLEEERRKLEEQIID 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	135/387 (35%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	118/282 (42%)
Septin14	NP_083102.1	CDC3	33..386	CDD:227352	135/375 (36%)
		CDC_Septin	48..314	CDD:206649	118/282 (42%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	58..65		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	110..113		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	193..196		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920