DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin7

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001107212.1	Gene:	Septin7 / 64551	RGDID:	620469	Length:	437	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	177/400 - (44%)
Similarity:	268/400 - (67%)	Gaps:	31/400 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SSSSGIEAVKCRPPIYPKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKST 100
            |:::...:|.|...: .:||..     ..|:|||.||.||:||||||||||||||||||||||||
  Rat     7 SAAAEERSVNCSTMV-AQPKNL-----EGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKST 65

  Fly   101 LINSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRV 165
            |||||||.||| :.:.|....||:||.:||:..:.|:|.||:|.||:|||||||||::..:.|:.
  Rat    66 LINSLFLTDLY-SPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQP 129

  Fly   166 CTQYIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIG 230
            ...|||.:|..|...||.:|||.:.||||.|||||:.|.||.|:.:|::.::|||.||||:.:|.
  Rat   130 VIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIA 194

  Fly   231 KADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILE 295
            |||.|..:|.::.|::|:::::::.|::|:|||.|.:|::...   :::|..:|.||||||||:|
  Rat   195 KADTLTPEECQQFKKQIMKEIQEHKIKIYEFPETDDEEENKLV---KKIKDRLPLAVVGSNTIIE 256

  Fly   296 VAGKKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHA 360
            |.||:||||||||||..||:.||.||..||..||.||||||||.|.:|||||:|::.::.::.:.
  Rat   257 VNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNG 321

  Fly   361 L---RERGKL-----------KRDSISSTNGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLK 411
            :   :.:|:|           :|:.::.....:..:.:...:.::  |::::::|...::|.:.:
  Rat   322 VDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVK--EKVQKLKDSEAELQRRHE 384

  Fly   412 QTHLMEMKKN 421
            |     ||||
  Rat   385 Q-----MKKN 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	169/368 (46%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	148/274 (54%)
Septin7	NP_001107212.1	CDC_Septin	47..317	CDD:206649	148/273 (54%)
		Interaction with SEPTIN12. /evidence=ECO:0000250\|UniProtKB:Q16181	47..317		148/273 (54%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	57..64		6/6 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	113..116		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	194..197		1/2 (50%)
		PRK12704	337..>433	CDD:237177	8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..437		5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930