DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin6

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001170795.1	Gene:	Septin6 / 56526	MGIID:	1888939	Length:	434	Species:	Mus musculus

Alignment Length:	385	Identity:	144/385 - (37%)
Similarity:	219/385 - (56%)	Gaps:	54/385 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKTT-- 127
            ::||.:||:|:..|||.:||.|.::.|||:|||||||:::||           |.:...|..|
Mouse    22 HVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLF-----------NTKFEGEPATHT 75

  Fly   128 ----KVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNR-- 186
                :::..|.|::|..|.|:||:|.|.||||.||.|||::...::||.||..|..:|..:.|
Mouse    76 QPGVQLQSNTYDLQESNVGLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVL 140

  Fly   187 RNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDL 251
            .:..|:|:|.||||:.|.||||:.:||..:::|..||||:.||.|:|.::|.|:.|.|.:|..:|
Mouse   141 HSYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPVIAKSDAISKSELAKFKIKITSEL 205

  Fly   252 EDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDP 316
            ..|.:|:||||    .:|:...:.:..:.|.:|||||||...:::..|.:|.||||||.|.||:.
Mouse   206 VSNGVQIYQFP----TDDESVSEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENE 266

  Fly   317 EHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRD------SISST 375
            .|.||:|||..||..:|:||::.|...|||.:| :|       .|.|.|....|      |:..|
Mouse   267 AHCDFVKLREMLIRVNMEDLREQTHARHYELYR-RC-------KLEEMGFKDTDPDSKPFSLQET 323

  Fly   376 NGFDAAISETDRLLLQKDEEIRRM---------------QDMLTQMQEKLKQTHLMEMKK 420
              ::|..:|....|.:|:||:|:|               :..|.:..::||:.|..|.||
Mouse   324 --YEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	142/383 (37%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	115/282 (41%)
Septin6	NP_001170795.1	CDC3	21..373	CDD:227352	139/375 (37%)
		CDC_Septin	39..307	CDD:206649	117/290 (40%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	49..56		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	101..104		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	184..187		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850