DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sep4 and sept10

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001017557.1	Gene:	sept10 / 550129	ZFINID:	ZDB-GENE-050417-3	Length:	429	Species:	Danio rerio

Alignment Length:	365	Identity:	140/365 - (38%)
Similarity:	215/365 - (58%)	Gaps:	37/365 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVE-ERIEKTTK 128
            ::||.:||:|:..||..:||.|.::.:||:|:|||||:::||      |....|.| ...|...|
Zfish    22 HVGFDSLPDQLVNKSTSQGFCFNILCIGETGIGKSTLMDTLF------NTNFENFESSHFEPKVK 80

  Fly   129 VEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNR--RNIQD 191
            :..:|.|::|..|||:||||:|.||||.:|.::|::....|||.||..|..:|..:.|  .|..|
Zfish    81 LRAQTYDLQESNVRLKLTVVNTVGFGDQMNKQESYQHIVDYIDTQFESYLQEELKIKRSLHNYHD 145

  Fly   192 NRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHI 256
            :|:|.||||:.|.||||:.:||..:::|..||||:.||.|||.::|.|:.|.|.:|:.:|..|.:
Zfish   146 SRIHACLYFIAPSGHSLKSLDLVTMKKLDSKVNIIPVIAKADTISKSELHKFKIKIMSELVSNGV 210

  Fly   257 QLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDF 321
            |:||||    .:|:...:.:..:...:|||||||...:.:..|.|:.||||||||.||:..|.||
Zfish   211 QIYQFP----IDDETVAKINTAMNGHLPFAVVGSTEEVNIGNKMVKARQYPWGVVQVENENHCDF 271

  Fly   322 IKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRDSISSTNGFDAAISETD 386
            :|||..||..:|:||::.|...|||.:|              |.||:.      .||.....|..
Zfish   272 VKLREMLICVNMEDLREQTHTRHYELYR--------------RCKLEE------MGFKDTDPECK 316

  Fly   387 RLLLQKDEEIRRMQDMLTQMQ---EKLKQTHLMEMKKNDS 423
            .:.||:..|.:| |:.|.::|   |:::||.:..:|:.::
Zfish   317 PVSLQQTYEAKR-QEFLGELQRREEEMRQTFVQRVKEKEA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	139/360 (39%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	116/277 (42%)
sept10	NP_001017557.1	CDC3	20..404	CDD:227352	140/365 (38%)
		CDC_Septin	39..307	CDD:206649	119/297 (40%)
		ATP-synt_B	<324..>410	CDD:304375	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950