DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN4

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001355700.1	Gene:	SEPTIN4 / 5414	HGNCID:	9165	Length:	996	Species:	Homo sapiens

Alignment Length:	396	Identity:	217/396 - (54%)
Similarity:	299/396 - (75%)	Gaps:	22/396 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SSGIEAVKCRP-PIYP--KPKTP--------SFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVV 91
            ||..:...|.| |:.|  :|::|        |.:.|::|:||||||.||||||||:||:|||||.
Human   604 SSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVA 668

  Fly    92 GESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDA 156
            ||||||||||:|||||.|||::|::...||||.:|.::.|..:||||:|||||||:|||||||||
Human   669 GESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDA 733

  Fly   157 INCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHR 221
            :|..:.|:...:|||:||.|||.|||||||:|||||||||||||:.|:||.||.:|::.::.||:
Human   734 VNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQ 798

  Fly   222 KVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFA 286
            :||||.::.|||.|...||...|.:|.:::|...|::||||:||||||:|||.||:.||.|||||
Human   799 RVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFA 863

  Fly   287 VVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQ 351
            |:||||::|..|::||||.||||:|.||:|.|.||:||||.|:.||||||||.|::.||||:|||
Human   864 VIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQ 928

  Fly   352 CISQISQHALRERGKLKRDSISSTNGFDAAI--------SETDRLLLQKDEEIRRMQDMLTQMQE 408
            ||..:::..::||   .|:.::..:|.|..|        .||::|:.:||||:||||:||.::|:
Human   929 CIQSMTRLVVKER---NRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQK 990

  Fly   409 KLKQTH 414
            ::|:.:
Human   991 QMKENY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	207/358 (58%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	171/274 (62%)
SEPTIN4	NP_001355700.1	DUF4655	2..534	CDD:317882
SEPTIN4	NP_001355700.1	Septin	660..932	CDD:307057	171/271 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	393	1.000	Domainoid score	I773
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1593
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm40503
orthoMCL	1	0.900	-	-		OOG6_104525
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870