DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN2

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_024308688.1	Gene:	SEPTIN2 / 4735	HGNCID:	7729	Length:	428	Species:	Homo sapiens

Alignment Length:	380	Identity:	211/380 - (55%)
Similarity:	282/380 - (74%)	Gaps:	33/380 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KCRPPIYPKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGD 109
            |.:|..:..|:||.      |:|||.||.||||||||:|||||||||||||||||||||||||.|
Human    70 KQQPTQFINPETPG------YVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTD 128

  Fly   110 LYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQF 174
            ||..|.:|...|:||:|.::|..|::||||||:||||||||||:||||||.|.::....||||||
Human   129 LYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQF 193

  Fly   175 RQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQE 239
            .:|..||||||||:|.|||||||.||:.|:||.|:.:|:..::.:|.|||||.||.|||.|..:|
Human   194 ERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKE 258

  Fly   240 VRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGR 304
            ..:||:|||.::|:::|::|..|:.:||||:|||:|.|.|||||||:|||||.::|..|||||||
Human   259 RERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGR 323

  Fly   305 QYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERG--KL 367
            .||||||.||:|||:||:||||.|| ||||||::.|||:||||||::.:         :||  |:
Human   324 LYPWGVVEVENPEHNDFLKLRTMLI-THMQDLQEVTQDLHYENFRSERL---------KRGGRKV 378

  Fly   368 KRDSISSTNGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLKQTHLMEMKKND 422
            :.:.::.           |::||:|:.|:||||:|:.:||.:::    |:|:..|
Human   379 ENEDMNK-----------DQILLEKEAELRRMQEMIARMQAQMQ----MQMQGGD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	205/356 (58%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	174/274 (64%)
SEPTIN2	XP_024308688.1	Septin	102..373	CDD:307057	174/280 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S763
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.810