DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN14

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_997249.2	Gene:	SEPTIN14 / 346288	HGNCID:	33280	Length:	432	Species:	Homo sapiens

Alignment Length:	408	Identity:	140/408 - (34%)
Similarity:	219/408 - (53%)	Gaps:	62/408 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQ---MPNVEERIEKT 126
            :.||..||.|:..:|:::||.|.::.|||:|:||||||::||..:|..|:.   ..||..:|:
Human    32 HFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQ-- 94

  Fly   127 TKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRR--NI 189
                  |.:::|..|:|:||||:|.|:||.|:.|.|::....|||.||..|..:|..:.|.  ..
Human    95 ------TYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEY 153

  Fly   190 QDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDN 254
            .|:|||.||||:.|.||||:.:||..::.|..||||:.:|.|||.::|.:::..|.:|:.:|..|
Human   154 HDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKNKIMSELISN 218

  Fly   255 HIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHS 319
            .||:||.|    .:::...|.:..:...:|||||||...::|..:.||||.|||||:.||:..|.
Human   219 GIQIYQLP----TDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVLQVENENHC 279

  Fly   320 DFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQIS-------------------------QH 359
            ||:|||..|:.|:|::||:.|...|||.:|.|.:.::.                         ..
Human   280 DFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYDQ 344

  Fly   360 ALRERGKLKRDSISSTNGFDAAISETDRLLLQK--------DEEIRRMQDMLTQMQ------EKL 410
            ..||..:||:..:......:|...|.::.|..|        .||||::::...|::      .|:
Human   345 CQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKM 409

  Fly   411 K------QTHLMEMKKND 422
            |      ||.|....|.|
Human   410 KAASEALQTQLSTDTKKD 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	138/404 (34%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	114/279 (41%)
SEPTIN14	NP_997249.2	CDC3	34..403	CDD:227352	133/380 (35%)
		CDC_Septin	49..317	CDD:206649	114/279 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	59..66		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	111..114		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	194..197		1/2 (50%)
		DUF342	<328..403	CDD:302792	13/74 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820