DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and sept5a

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_956282.1	Gene:	sept5a / 335925	ZFINID:	ZDB-GENE-030131-7868	Length:	369	Species:	Danio rerio

Alignment Length:	361	Identity:	209/361 - (57%)
Similarity:	277/361 - (76%)	Gaps:	21/361 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 KDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEK 125
            :|:.|:||||||.||||||||:||:|||||.||||||||||:|||||.||||:|::.|.||||.:
Zfish    18 EDKQYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYKDRKLLNAEERINQ 82

  Fly   126 TTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQ 190
            |.::.|.|:||||:||:|:||:|||||||||:|..:.||..|.|||:||.|||.|||||||:||.
Zfish    83 TVEITKHTVDIEEKGVKLKLTIVDTPGFGDAVNNNECWRPITDYIDQQFEQYFRDESGLNRKNIL 147

  Fly   191 DNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNH 255
            ||||||||||:||:||.||.:|::.::.||.||||:.:|.|||||...||:|||:|:..::|...
Zfish   148 DNRVHCCLYFIPPFGHGLRPVDVEFMKALHEKVNIIPLISKADCLTPTEVKKLKDRVRDEIERFG 212

  Fly   256 IQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSD 320
            |::||||||||||:::|||.|:|||...||||:||||::|..|::||||.||||:|.||:..|.|
Zfish   213 IKVYQFPECDSDEEEEFKQMDKELKECTPFAVIGSNTVVEARGQRVRGRLYPWGIVEVENQSHCD 277

  Fly   321 FIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRDSISSTNGFDAAIS-- 383
            |:|||..||.:||.||||.|.||||||:||.||.:::       .||.:|     |..|:.:.
Zfish   278 FVKLRNMLIRSHMHDLKDVTCDVHYENYRAHCIQEMT-------SKLAQD-----NRTDSPLPIL 330

  Fly   384 -------ETDRLLLQKDEEIRRMQDMLTQMQEKLKQ 412
                   ||::|:..||||::|||:||.:||:::.:
Zfish   331 PLPTPDVETEKLIKMKDEELKRMQEMLEKMQQQMHE 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	208/357 (58%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	174/274 (64%)
sept5a	NP_956282.1	CDC3	21..367	CDD:227352	208/358 (58%)
sept5a	NP_956282.1	Septin	39..312	CDD:279124	174/272 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I744
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1525
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm24872
orthoMCL	1	0.900	-	-		OOG6_104525
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870