DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and sept8a

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001108589.1	Gene:	sept8a / 321590	ZFINID:	ZDB-GENE-030131-309	Length:	420	Species:	Danio rerio

Alignment Length:	376	Identity:	142/376 - (37%)
Similarity:	225/376 - (59%)	Gaps:	37/376 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKTTKV 129
            ::||.:||:|:..|||.:||.|.::.|||:|:|||||:|:|| ..:::|.:..:.:..:    .:
Zfish    22 HVGFDSLPDQLVSKSVTQGFCFNILCVGETGIGKSTLMNTLF-NTMFENEEASHYQNGV----YL 81

  Fly   130 EKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRR--NIQDN 192
            ..:|.|::|..|.|:||:|||.||||.||.|:|::....|||.||..|..:|..:.|.  |..|.
Zfish    82 RPRTYDLQESNVHLKLTIVDTVGFGDQINKEESYKPIVDYIDTQFENYLQEELKVKRSLFNYHDT 146

  Fly   193 RVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHIQ 257
            |:|.||||:.|.||||:.:||..:::|..||||:.:|.|||.::|.|:.|.|.:|:.:|..|.:|
Zfish   147 RIHICLYFISPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMSELVSNGVQ 211

  Fly   258 LYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDFI 322
            :||||    .:|:...:.:..:.|.:|||||||...::|..|.||.||||||||.||:..|.||:
Zfish   212 IYQFP----TDDEAVTEINSSMNAHLPFAVVGSVEEVKVGNKTVRARQYPWGVVQVENESHCDFV 272

  Fly   323 KLRTFLISTHMQDLKDTTQDVHYENFRAQCISQI--------SQ-HALRERGKLKRDS------- 371
            |||..||..:|:||::.|...|||.:|...:.::        || .:|:|..:.||..
Zfish   273 KLREMLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSQPFSLQETYEAKRKEFLGDLQK 337

  Fly   372 ---------ISSTNGFDAAISETDRLLLQKDEEIRRM-QDMLTQMQEKLKQ 412
                     ::.....:|.:.|.:|.|.:|.|:::|| |:...:::||.::
Zfish   338 KEEEMRQMFVNKVKETEAELKEKERELHEKFEQLKRMHQEEKRKVEEKRRE 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	142/376 (38%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	117/284 (41%)
sept8a	NP_001108589.1	CDC3	21..382	CDD:227352	140/368 (38%)
		CDC_Septin	39..307	CDD:206649	117/276 (42%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	49..56		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	101..104		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	184..187		1/2 (50%)
		Syntaphilin	<330..>377	CDD:291936	8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820