DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sep4 and Septin1

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001012478.1	Gene:	Septin1 / 293507	RGDID:	1307216	Length:	366	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	186/355 - (52%)
Similarity:	269/355 - (75%)	Gaps:	3/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKT 126
            |::|:|||.||.|:||||||:||:|||||.||||||||||||||||.:||::||:|:...|..:|
  Rat     2 DKEYVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPDASARTTQT 66

  Fly   127 TKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQD 191
            ..:|::.::|||.|::::||:||||||||:::|.|.|....::|:|||.||..|||||||:||||
  Rat    67 LTIERRGVEIEEGGIKVKLTLVDTPGFGDSVDCSDCWLPVVRFIEEQFEQYLRDESGLNRKNIQD 131

  Fly   192 NRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHI 256
            :||||||||:.|:|..||.:|:..:|.:|.||||:.||||||.|..:|.:.||::|...|::..|
  Rat   132 SRVHCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADALLPRETQVLKQKIRDQLKEEEI 196

  Fly   257 QLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDF 321
            .:|||||||||||::||:|:.|:|.:||||||||:.::....:.||||:|.||.|.||:|.|.||
  Rat   197 NIYQFPECDSDEDEEFKKQNEEMKENIPFAVVGSSEVVREGTRPVRGRRYSWGTVEVENPHHCDF 261

  Fly   322 IKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRE---RGKLKRDSISSTNGFDAAIS 383
            :.||..|:.||:||||:.|.|:.||.:||:|:..:::...|:   |.||.|.|.:........::
  Rat   262 LNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLA 326

  Fly   384 ETDRLLLQKDEEIRRMQDMLTQMQEKLKQT 413
            :|::|:.:||||:||||:||.:||.:::|:
  Rat   327 DTEKLIREKDEELRRMQEMLEKMQAQMQQS 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	185/352 (53%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	151/274 (55%)
Septin1	NP_001012478.1	CDC3	5..348	CDD:227352	182/342 (53%)
		Septin	22..295	CDD:279124	151/272 (56%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	32..39		6/6 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	89..92		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	170..173		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..366		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11865
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm44646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.890