DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin4

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_038941491.1	Gene:	Septin4 / 287606	RGDID:	1308781	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	220/398 - (55%)
Similarity:	300/398 - (75%)	Gaps:	22/398 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SSSSGIEAVKCRP-PIYP--KPKTP--------SFDKDRDYIGFATLPEQVHRKSVKRGFEFTLM 89
            |..|..:...|.| |:.|  :|::|        |.:.|::|:||||||.||||||||:||:||||
  Rat   606 SQPSDSQQYFCPPAPLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLM 670

  Fly    90 VVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFG 154
            |.||||||||||:|||||.|||::|::...||||.:|.::.|..:||||:|||||||:|||||||
  Rat   671 VAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFG 735

  Fly   155 DAINCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRL 219
            ||:|..:.||...:|||:||.|||.|||||||:|||||||||||||:.|:||.||.:|::.::.|
  Rat   736 DAVNNTECWRPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKAL 800

  Fly   220 HRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIP 284
            |::||||.::.|||.|...||.:.|.:|.:::|...|::||||:||||||:|||.||:.||.|||
  Rat   801 HQRVNIVPILAKADTLTPSEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIP 865

  Fly   285 FAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFR 349
            |||:||||::|..|::||||.||||:|.||:|.|.||:||||.|:.||||||||.|::.||||:|
  Rat   866 FAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYR 930

  Fly   350 AQCISQISQHALRERGKLKRDSISSTNGFDAAI--------SETDRLLLQKDEEIRRMQDMLTQM 406
            ||||..:::..::||   .|:.::..:|.|..|        .||::|:.:||||:||||:||.::
  Rat   931 AQCIQSMTRLVVKER---NRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKI 992

  Fly   407 QEKLKQTH 414
            |.::|:||
  Rat   993 QRQMKETH 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	210/358 (59%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	172/274 (63%)
Septin4	XP_038941491.1	DUF4655	14..538	CDD:406085
Septin4	XP_038941491.1	Septin	664..936	CDD:395596	172/271 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134084
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1514
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm44646
orthoMCL	1	0.900	-	-		OOG6_104525
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880