DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and spn6

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001342876.1	Gene:	spn6 / 2538950	PomBaseID:	SPCC188.12	Length:	380	Species:	Schizosaccharomyces pombe

Alignment Length:	368	Identity:	116/368 - (31%)
Similarity:	194/368 - (52%)	Gaps:	29/368 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERI-EKTTKVEKKT 133
            :||.:......::....|:|:.|.||.||:|..|:||...|...:.....:|.| :||.:|:|..
pombe    15 SLPSKRENLIKRKECGLTIMLCGASGTGKTTFFNTLFATSLQPEKSYETAKETIAKKTLEVKKNK 79

  Fly   134 MDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQDNRVHCCL 198
            ..|||.|..:.|||:|||||||.|:....|....:|:|||..:|...:....|...:|.|||.||
pombe    80 AVIEEDGFHINLTVLDTPGFGDFIDNTSCWNTVAEYLDEQHERYLIHDQNSLRVPRKDTRVHVCL 144

  Fly   199 YFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHIQLYQFPE 263
            ||:.|....:..:|:..::.|...||:|.||.|||.....|:.::|::|.:.||...|.::.
pombe   145 YFITPVSFGMLPLDVLAMKELSTHVNLVPVIAKADTFTTPELTQIKQKIRRILEAQSIDVFH--- 206

  Fly   264 CDSDEDDDFKQQDRELKASIPFAVVGS-NTILEVAGKKVRGRQYPWGVVNVEDPEHSDFIKLRTF 327
             .|.|..|::..:. |.:|:|:|::.| |.:.:..|:|.:||:||||...:.:..|.||:||:..
pombe   207 -PSTEYSDYETAEL-LDSSLPYAIISSVNEVCKDDGEKSQGRRYPWGTSEIYEETHCDFLKLKKL 269

  Fly   328 LISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERG--KLKRDSISSTNGFDAAI-------- 382
            ||:.||.:|.:||:...||.:|.:.::.      |:.|  |||::.....|....||
pombe   270 LINRHMLELINTTETNIYERYRREQLTN------RKSGIPKLKKEHYERLNNEKRAIQQKITQMT 328

  Fly   383 SETDRLLLQKDEEIRRMQDM----LTQMQEKLK--QTHLMEMK 419
            :||:.....|:|::...:|.    |::..|:::  :|.:..:|
pombe   329 NETESFFQAKEEKMIETRDALNSELSEYHERIRALETQIESLK 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	116/368 (32%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	97/276 (35%)
spn6	NP_001342876.1	CDC3	17..375	CDD:227352	115/366 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	233	1.000	Domainoid score	I490
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920