DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN8

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001092281.1	Gene:	SEPTIN8 / 23176	HGNCID:	16511	Length:	483	Species:	Homo sapiens

Alignment Length:	380	Identity:	149/380 - (39%)
Similarity:	223/380 - (58%)	Gaps:	39/380 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQM 116
            |:|::.|..   .::||.:||:|:..|||.:||.|.::.|||:|:|||||:|:||      |...
Human    14 PEPRSLSLG---GHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLF------NTTF 69

  Fly   117 PNVE-ERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTD 180
            ...| ...|...::..:|.|::|..|:|:||:||..||||.||.::|:|....|||.||..|..:
Human    70 ETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQE 134

  Fly   181 ESGLNRR--NIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKL 243
            |..:.|.  :..|.|:|.||||:.|.||||:.:||..:::|..||||:.:|.|||.::|.|:.|.
Human   135 ELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKF 199

  Fly   244 KERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPW 308
            |.:|:.:|..|.:|:||||    .:|:...:.:..:.|.:|||||||...::|..|.||.|||||
Human   200 KIKIMGELVSNGVQIYQFP----TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPW 260

  Fly   309 GVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRD--- 370
            |||.||:..|.||:|||..||..:|:||::.|...|||.:| :|       .|.|.|....|
Human   261 GVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYR-RC-------KLEEMGFQDSDGDS 317

  Fly   371 ---SISSTNGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLKQTHLMEMKKND 422
               |:..|  ::|...|....|.:|:||:|:|      ...|:|:|.| |:|:.:
Human   318 QPFSLQET--YEAKRKEFLSELQRKEEEMRQM------FVNKVKETEL-ELKEKE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	145/363 (40%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	118/277 (43%)
SEPTIN8	NP_001092281.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/7 (43%)
		CDC_Septin	41..309	CDD:206649	120/285 (42%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	51..58		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	103..106		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	186..189		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850