DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin8

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001334425.1	Gene:	Septin8 / 20362	MGIID:	894310	Length:	484	Species:	Mus musculus

Alignment Length:	379	Identity:	149/379 - (39%)
Similarity:	226/379 - (59%)	Gaps:	37/379 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQM 116
            |:|::.|..   .::||.:||:|:..|||.:||.|.::.|||:|:|||||:|:|| ...::..:.
Mouse    14 PEPRSLSLG---GHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLF-NTTFETEEA 74

  Fly   117 PNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDE 181
            .:.||.:    ::..:|.|::|..|.|:||:||..||||.||.:||:|....|||.||..|..:|
Mouse    75 SHHEECV----RLRPQTYDLQESNVHLKLTIVDAVGFGDQINKDDSYRPIVDYIDAQFENYLQEE 135

  Fly   182 SGLNRR--NIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLK 244
            ..:.|.  :..|.|:|.||||:.|.||||:.:||..:::|..||||:.:|.|||.::|.|:.|.|
Mouse   136 LKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFK 200

  Fly   245 ERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWG 309
            .:|:.:|..|.:|:||||    .:|:...:.:..:.|.:|||||||...::|..|.||.||||||
Mouse   201 IKIMGELVSNGVQIYQFP----TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWG 261

  Fly   310 VVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRD---- 370
            ||.||:..|.||:|||..||..:|:||::.|...|||.:| :|       .|.|.|....|
Mouse   262 VVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYR-RC-------KLEEMGFQDSDGDSQ 318

  Fly   371 --SISSTNGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLKQTHLMEMKKND 422
              |:..|  ::|...|....|.:|:||:|:|      ...|:|:|.| |:|:.:
Mouse   319 PFSLQET--YEAKRKEFLSELQRKEEEMRQM------FVNKVKETEL-ELKEKE 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	145/362 (40%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	118/276 (43%)
Septin8	NP_001334425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/11 (27%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	51..58		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	103..106		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	186..189		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..429
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850