DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin4

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_006532556.1	Gene:	Septin4 / 18952	MGIID:	1270156	Length:	971	Species:	Mus musculus

Alignment Length:	384	Identity:	215/384 - (55%)
Similarity:	295/384 - (76%)	Gaps:	21/384 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PIYP--KPKTP--------SFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLIN 103
            |:.|  :|::|        |.:.|::|:||||||.||||||||:||:|||||.||||||||||:|
Mouse   591 PLSPSSRPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVN 655

  Fly   104 SLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQ 168
            ||||.|||::|::...||||.:|.::.|..:||||:|||||||:|||||||||:|..:.|:...:
Mouse   656 SLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAE 720

  Fly   169 YIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKAD 233
            |||:||.|||.|||||||:|||||||||||||:.|:||.||.:|::.::.||::||||.::.|||
Mouse   721 YIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKAD 785

  Fly   234 CLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAG 298
            .|...||.:.|.:|.:::|...|::||||:||||||:|||.||:.||.||||||:||||::|..|
Mouse   786 TLTPPEVDRKKCKIREEIEHFGIKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARG 850

  Fly   299 KKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRE 363
            ::||||.||||:|.||:|.|.||:||||.|:.||||||||.|::.||||:|||||..:::..::|
Mouse   851 RRVRGRLYPWGIVEVENPGHCDFVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKE 915

  Fly   364 RGKLKRDSISSTNGFDAAI--------SETDRLLLQKDEEIRRMQDMLTQMQEKLKQTH 414
            |   .|:.::..:|.|..|        .||::|:.:||||:||||:||.::|.::|:||
Mouse   916 R---NRNKLTRESGTDFPIPAVPPGTDPETEKLIREKDEELRRMQEMLHKIQRQMKETH 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	209/358 (58%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	171/274 (62%)
Septin4	XP_006532556.1	DUF4655	14..509	CDD:373934
Septin4	XP_006532556.1	Septin	634..914	CDD:366275	171/279 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I775
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1571
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm42576
orthoMCL	1	0.900	-	-		OOG6_104525
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870