DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN1

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_016878480.1	Gene:	SEPTIN1 / 1731	HGNCID:	2879	Length:	494	Species:	Homo sapiens

Alignment Length:	384	Identity:	190/384 - (49%)
Similarity:	261/384 - (67%)	Gaps:	38/384 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TMGATAAGGVASVISTMNGSSSSGIEAVKCRPPIYPKPKTPSFDKDRDYIGFATLPEQVHRKSVK 81
            |.||..||||                                  .|::|:|||.||.|:||||||
Human    38 TAGAVMAGGV----------------------------------MDKEYVGFAALPNQLHRKSVK 68

  Fly    82 RGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLT 146
            :||:|||||.||||||||||||||||.:||::||:|....|:.:|..:|::.::|||.||:::||
Human    69 KGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPEASARLTQTLAIERRGVEIEEGGVKVKLT 133

  Fly   147 VVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQM 211
            :||||||||:::|.|.|....::|:|||.||..|||||||:||||:||||||||:.|:|..||.:
Human   134 LVDTPGFGDSVDCSDCWLPVVKFIEEQFEQYLRDESGLNRKNIQDSRVHCCLYFISPFGRGLRPL 198

  Fly   212 DLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQD 276
            |:..:|.:|.||||:.||||||.|..||.:.||::|...|::..|.:|||||||||||:|||:||
Human   199 DVAFLRAVHEKVNIIPVIGKADALMPQETQALKQKIRDQLKEEEIHIYQFPECDSDEDEDFKRQD 263

  Fly   277 RELKASIPFAVVGSNTILEVAGKK-VRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTT 340
            .|:|.|||||||||..::...|.: ||||:|.||.|.||:|.|.||:.||..|:.||:||||:.|
Human   264 AEMKESIPFAVVGSCEVVRDGGNRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDLKEVT 328

  Fly   341 QDVHYENFRAQCISQISQHALRE---RGKLKRDSISSTNGFDAAISETDRLLLQKDEEI 396
            .|:.||.:||:|:..:::...|:   |.||.|.|.:........:::|::|:.:||||:
Human   329 HDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLADTEKLIREKDEEV 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	182/336 (54%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	157/275 (57%)
SEPTIN1	XP_016878480.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1593
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm40503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.080