DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and SEPTIN12

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_016878427.1	Gene:	SEPTIN12 / 124404	HGNCID:	26348	Length:	364	Species:	Homo sapiens

Alignment Length:	319	Identity:	130/319 - (40%)
Similarity:	193/319 - (60%)	Gaps:	10/319 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PIYPKPKTPSFDKDRDYIGFATLP-EQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYK 112
            |....|.|.:..:.|..:.:...| |.|.  |.:|......:..|:|||||||::|:||...::|
Human    20 PSEAPPLTATIFRIRPSLTWEDFPGESVF--SAQRRISLGDIPRGQSGLGKSTMVNTLFKSKVWK 82

  Fly   113 NRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQY 177
            :.. |.:.....:|.::...|..|||:||:|:|||.|||||||.||.::.|.....||:||:.||
Human    83 SNP-PGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQY 146

  Fly   178 FTDESGLNR-RNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVR 241
            ..:|..:.| |:|.|.|||||:|||||.||.||.:|::.::||.|.||:|.||.:||.|..:|..
Human   147 LQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEERE 211

  Fly   242 KLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQY 306
            ..:.||.|:|..:.|.:|  |:...|||.:.|..:.:|:..|||||||::....|.|:.|.||:.
Human   212 AFRRRIQQNLRTHCIDVY--PQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKT 274

  Fly   307 PWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERG 365
            .||::.||:..|.:|..||..||.:|:|||||.|.::||||:|   :.::::..|..||
Human   275 KWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYR---VIRLNESHLLPRG 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	126/303 (42%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	119/275 (43%)
SEPTIN12	XP_016878427.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850