DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and Septin10

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001365992.1	Gene:	Septin10 / 103080	MGIID:	1918110	Length:	456	Species:	Mus musculus

Alignment Length:	393	Identity:	144/393 - (36%)
Similarity:	226/393 - (57%)	Gaps:	53/393 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQMPNVEERIEKT--- 126
            ::||.:||:|:..:|:::||.|.::.|||:|:|||||||:||         ..|.|| :|.:
Mouse    23 HVGFESLPDQLVDRSIEQGFCFNILCVGETGIGKSTLINTLF---------NTNFEE-LESSHFC 77

  Fly   127 --TKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTDESGLNRR-- 187
              .::..:|.:::|..|||:||:|:|.||||.||.|||::....|||:||..|..:|..:.|.
Mouse    78 PCVRLRAQTYELQESNVRLKLTIVNTVGFGDQINKEDSYQPIVDYIDDQFEAYLQEELKIKRALF 142

  Fly   188 NIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKERILQDLE 252
            |..|:|:|.||||:.|.|||||.:||..::.|..||||:.:|.|||.::|.|::|.|.:::.:|.
Mouse   143 NYHDSRIHVCLYFIAPTGHSLRTLDLLTMKSLDNKVNIIPLIAKADTISKSELQKFKMKLMNELV 207

  Fly   253 DNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGVVNVEDPE 317
            .|.:|:||||    .:||...:.:..:...:|||||||...::|..|.|:|||||||:|.||:..
Mouse   208 INGVQIYQFP----TDDDTTSKINGAMNGHLPFAVVGSMDEIKVGNKMVKGRQYPWGIVQVENEN 268

  Fly   318 HSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQ---------------------ISQHAL 361
            |.||:|||..||.|:|:||::.|...|||.:| :|..|                     ..:|..
Mouse   269 HCDFVKLREMLICTNMEDLREQTHMRHYELYR-RCKLQEMGFVDMGPENKPLSLQETYEAKRHEF 332

  Fly   362 -----RERGKLKRDSISSTNGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLKQTHLMEMKKN 421
                 |:..::|:..:......:|.:.|.:|.|..|.|.::|:     ..:|::|......|.:.
Mouse   333 YGERQRKEEQMKQMFVQRVKEKEAILKEAERELQAKFEHLKRI-----HQEERMKLEEKRRMLEE 392

  Fly   422 DSV 424
            :||
Mouse   393 ESV 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	142/387 (37%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	123/302 (41%)
Septin10	NP_001365992.1	CDC_Septin	40..308	CDD:206649	123/282 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	50..57		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	102..105		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	185..188		1/2 (50%)
		PTZ00121	<274..426	CDD:173412	31/128 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850