DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and septin2

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001090723.1	Gene:	septin2 / 100036706	XenbaseID:	XB-GENE-480201	Length:	355	Species:	Xenopus tropicalis

Alignment Length:	361	Identity:	201/361 - (55%)
Similarity:	267/361 - (73%)	Gaps:	24/361 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YPKPKTPSFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTLINSLFLGDLYKNRQ 115
            :..|:||.      |:|||.||.|||||||::|||||||||||||||||||||||||.|||..|.
Frog     8 FTNPETPG------YVGFANLPNQVHRKSVRKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERV 66

  Fly   116 MPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVCTQYIDEQFRQYFTD 180
            :|...::||:|.::|..|::||||||:||||||||||:|||:||.|.::....|:|.||.:|..|
Frog    67 VPGAADKIERTVEIEASTVEIEERGVKLRLTVVDTPGYGDAMNCVDCFKPIISYVDNQFERYLHD 131

  Fly   181 ESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGKADCLNKQEVRKLKE 245
            |||||||:|.|||||||.||:.|:||.|:.:|::.::.||.|||||.||.|||.|..:|..:||.
Frog   132 ESGLNRRHIVDNRVHCCFYFISPFGHGLKPLDVEFMKALHNKVNIVPVIAKADTLTLRERERLKR 196

  Fly   246 RILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEVAGKKVRGRQYPWGV 310
            |:|.::|::.|::||.|:.:||||:|||:|.|.|||||||.|||||.::|..|||||||.|||||
Frog   197 RVLDEIEEHGIKIYQLPDAESDEDEDFKEQTRLLKASIPFTVVGSNQLIEAKGKKVRGRLYPWGV 261

  Fly   311 VNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHALRERGKLKRDSISST 375
            |.||:|||:||:||||.|| ||||||::.|||:||||||::              :||:...|..
Frog   262 VEVENPEHNDFLKLRTMLI-THMQDLQEVTQDLHYENFRSE--------------RLKKGVASKV 311

  Fly   376 NGFDAAISETDRLLLQKDEEIRRMQDMLTQMQEKLK 411
            ...:..   .|::|.:|:.|:||||:|:.:||.:::
Frog   312 ENVEVT---KDQILQEKEAELRRMQEMIARMQAQMQ 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	198/347 (57%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	171/274 (62%)
septin2	NP_001090723.1	Septin	33..313	CDD:366275	174/294 (59%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	43..50		6/6 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	100..103		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	181..184		1/2 (50%)
		Important for dimerization. /evidence=ECO:0000250	259..269		7/9 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960