DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep4 and sept4b

DIOPT Version :9

Sequence 1:	NP_573147.2	Gene:	Sep4 / 32646	FlyBaseID:	FBgn0259923	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_021336990.1	Gene:	sept4b / 100003446	ZFINID:	ZDB-GENE-071127-1	Length:	508	Species:	Danio rerio

Alignment Length:	447	Identity:	234/447 - (52%)
Similarity:	314/447 - (70%)	Gaps:	42/447 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KHQP---------------PPPPLPLSQP-----PTMGATAAGGVASVISTMNGSSSSGIEAVKC 46
            ||.|               ||||...::|     ||:...||........:..|.....:| ...
Zfish    56 KHLPKEDSEDSELEHIMGRPPPPEGHNRPHTPGTPTLRPAAAPRGPGEHESRTGGQRGRVE-FSL 119

  Fly    47 RPPIYP-KPKTP---------SFDKDRDYIGFATLPEQVHRKSVKRGFEFTLMVVGESGLGKSTL 101
            ..||.| :||:|         :.|:|::|:||||||.||||||||:||:|||||.||||||||||
Zfish   120 PSPISPSRPKSPWGRYDPYDATEDQDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTL 184

  Fly   102 INSLFLGDLYKNRQMPNVEERIEKTTKVEKKTMDIEERGVRLRLTVVDTPGFGDAINCEDSWRVC 166
            :|||||.||||:|::.|.||||.:|.::.|.|:||||:||:|:||:|||||||||:|..:.|:..
Zfish   185 VNSLFLTDLYKDRKLLNAEERITQTVEITKHTVDIEEKGVKLKLTIVDTPGFGDAVNNTECWKSV 249

  Fly   167 TQYIDEQFRQYFTDESGLNRRNIQDNRVHCCLYFVPPWGHSLRQMDLDLIRRLHRKVNIVLVIGK 231
            ..|||:||.|||.|||||||:|||||||||||||:.|:||.||.:|::.::.||.|||||.|:.|
Zfish   250 ADYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHEKVNIVPVLAK 314

  Fly   232 ADCLNKQEVRKLKERILQDLEDNHIQLYQFPECDSDEDDDFKQQDRELKASIPFAVVGSNTILEV 296
            ||.|...||:|.|.:|.:::|...|::||||:||||||::|||||:|||.||||||:||||::|.
Zfish   315 ADTLTPLEVKKKKIKIREEIEQYGIKIYQFPDCDSDEDEEFKQQDQELKDSIPFAVIGSNTVVEA 379

  Fly   297 AGKKVRGRQYPWGVVNVEDPEHSDFIKLRTFLISTHMQDLKDTTQDVHYENFRAQCISQISQHAL 361
            .||:||||.||||:|.||:|.|.||:|||..|:.||||||||.|::.||||:||.||..:::..:
Zfish   380 KGKRVRGRLYPWGIVEVENPAHCDFVKLRNMLVRTHMQDLKDVTRETHYENYRAHCIQSMTRMVV 444

  Fly   362 RERGKLKRDSISSTNGFDAAI--------SETDRLLLQKDEEIRRMQDMLTQMQEKL 410
            :||   .|:.::..:|.|..|        |||::|:.:||||:||||:||.::||::
Zfish   445 KER---NRNKLTRESGTDFPIPTAPGVSDSETEKLIREKDEELRRMQEMLQKIQEQM 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep4	NP_573147.2	CDC3	65..420	CDD:227352	212/354 (60%)
Sep4	NP_573147.2	CDC_Septin	82..357	CDD:206649	175/274 (64%)
sept4b	XP_021336990.1	Atrophin-1	<12..130	CDD:331285	18/74 (24%)
sept4b	XP_021336990.1	Septin	166..438	CDD:307057	175/271 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I744
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1525
OMA	1	1.010	-	-		QHG51878
OrthoDB	1	1.010	-	-		D452703at33208
OrthoFinder	1	1.000	-	-		FOG0000103
OrthoInspector	1	1.000	-	-		otm24872
orthoMCL	1	0.900	-	-		OOG6_104525
Panther	1	1.100	-	-	LDO	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X204
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980