DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ANO3

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001300655.1	Gene:	ANO3 / 63982	HGNCID:	14004	Length:	1042	Species:	Homo sapiens

Alignment Length:	827	Identity:	187/827 - (22%)
Similarity:	307/827 - (37%)	Gaps:	256/827 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SPGPRTRN---IIENQLFRRQRSLKLEALQRQRTLDSNDGVEGLGADTEP--------FDKTHI- 59
            |.||..::   .|:..|..|:.:::.:   ::.|.:.|...|||..:.||        |.|.||
Human   213 SSGPLFKDGKKRIDYILVYRKTNIQYD---KRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIP 274

  Fly    60 ---VIIFTEKAKLR-----HCQDVEKIIQEFG-IQTTLEIVGKTEKYLYLSASVDTLLRLADAAE 115
               :..:.|:..:|     .|...:...:..| :||...   :.:.::..:..|.......|..|
Human   275 WDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFR---RIKNWMAQNPMVLDKSAFPDLEE 336

  Fly   116 LEKMTTTHSMQKFNHGCIS--DFLLPGMGKEQILRY-CEIPVLIKDVIQDGIKSYVQKGYIEDMF 177
            .:..|...|..:.:|..|:  |.......:.:|:.: .|.......:.:.||:..:..|.....|
Human   337 SDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAF 401

  Fly   178 PLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGSSIGLYFGFIEFYTKA 223
            |.|:                   :||.....|.:.....|::.||.|||..|||||.::.:||..
Human   402 PPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGM 466

  Fly   224 LIFPSLFGILQY---VFDLNISLV-------------------CS-------------------- 246
            ||..::.|:..:   :|.:|.|.|                   ||
Human   467 LIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNG 531

  Fly   247 -------FYVVWTTIFLELWKRKCAGYSYRWGTIEMSSLDKPRSAYTGQLKP------------D 292
                   |..:|.|:|||.|||:.:..:|.|..||....::       .|:|            :
Human   532 GTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEE-------TLRPQFEAKYYKMEIVN 589

  Fly   293 PITGKMTLHYPMRYTYLQMYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLYV---- 353
            |||||...|.|.          |..|....|..:|.|    |.|...:.|.||...:.|.|
Human   590 PITGKPEPHQPS----------SDKVTRLLVSVSGIF----FMISLVITAVFGVVVYRLVVMEQF 640

  Fly   354 -------------------PVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRVNKLMLF 399
                               .|.:..::|.:.:.||||:|..|||||..||.|:::.....|:.||
Human   641 ASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLF 705

  Fly   400 EIVNNFFSQFYIAFVLHDL--RQLKYQ---------------------LMMQLLVF--QLLCIAQ 439
            :.||...|.|||||.|...  ...||.                     |.|.:::|  |:.....
Human   706 QFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFM 770

  Fly   440 EIGIPLLAVLRQKYAEFRHREVAEEKLRSISD--LPRYEQSFYESGLDEYHSTYEDYLQVCIQFG 502
            |:|.||:    |.:.. ||:     ..|.|.|  :|::|..:....:: .|...::||::.:|||
Human   771 ELGYPLI----QNWWS-RHK-----IKRGIHDASIPQWENDWNLQPMN-LHGLMDEYLEMVLQFG 824

  Fly   503 FVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNC 567
            |..:|.|..|.|.:.|||||:..:.:|.:|....::||...||.:||.|....|.:.::::::|.
Human   825 FTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNA 889

  Fly   568 GLL---------------------FLQP----------NVKDFF--------------------- 580
            .::                     .::|          |...||
Human   890 FVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGP 954

  Fly   581 -----------SHWLPSVPDLSFVI-FEHLLLGLKFLIHKVIHERPR 615
                       .:|......|:|:| ||||:.|:|..|..:|.:.|:
Human   955 PWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPK 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	144/589 (24%)
ANO3	NP_001300655.1	Anoct_dimer	218..442	CDD:292796	39/229 (17%)
ANO3	NP_001300655.1	Anoctamin	445..1011	CDD:282414	144/589 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920