DRSC/TRiP Functional Genomics Resources

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Protein Alignment Axs and ANO8

DIOPT Version :9

Sequence 1:NP_476777.1 Gene:Axs / 32645 FlyBaseID:FBgn0000152 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_066010.1 Gene:ANO8 / 57719 HGNCID:29329 Length:1232 Species:Homo sapiens


Alignment Length:792 Identity:191/792 - (24%)
Similarity:314/792 - (39%) Gaps:258/792 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 TEKY-LYLSASVDTLLRLADAAELEKMTTTHSMQKFNHG-----CISDFLLPGMGKE-------- 144
            |..| .:::|:.::|||.||...|.|....    :|..|     |..||:...:..|        
Human   104 TRAYAFFVTATYESLLRGADELGLRKAVKA----EFGGGTRGFSCEEDFIYENVESELRFFTSQE 164

  Fly   145 ---------QILRYCEIPVL-----IKDVIQDGIKSYVQKGYIEDMFPLHDILYLERF--NW-NL 192
                     |.||..:...|     ::|  |..|.....:|.|:.:||:|:...|.|.  :| ..
Human   165 RQSIIRFWLQNLRAKQGEALHNVRFLED--QPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQA 227

  Fly   193 KRTKLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF--------DLNISLVCSFYV 249
            .....|::||.:|||..|.:||.::.|||.|:::|::||.:.|.|        |::..:...|.|
Human   228 VCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNV 292

  Fly   250 VWTTIFLELWKRKCAGYSYRWGTIEM--SSLDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMY 312
            :|:|:|||.|||:.|..:|:|||::.  .::::||..:.|..:..|||.....:||.....|...
Human   293 IWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQL 357

  Fly   313 CISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLT 377
            .:|.|:.|.|:|......|..||::..||:..|......::|.::.::|:::.:..|:|||.:|.
Human   358 LVSLPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIWLN 422

  Fly   378 NLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLL------- 435
            ::||:|..|.|::|.:.|::||:.||::.|.|||.|.|.|:.:||..|...|:..|.|       
Human   423 DMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFLQNVREVL 487

  Fly   436 ---------------------------------------------------------CIAQEIGI 443
                                                                     |::...|.
Human   488 QPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGGGGRRCLSGGCGA 552

  Fly   444 P------------------------------------------------------LLAVLRQKYA 454
            |                                                      |...||.|..
Human   553 PEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEEEGEEGGLLDCGLRLKKV 617

  Fly   455 EFRHR--------------------------------EVAEE----------------------- 464
            .|..|                                .:|||                       
Human   618 SFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEEDDEAEGAPGSPEREPPAILFRRA 682

  Fly   465 ---------------KLRSISD---------------------LPRYEQSFYESGLDEYHSTYED 493
                           :..|.||                     .|:..|:..||.:.:|..|::|
Human   683 GGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQD 747

  Fly   494 YLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELL 558
            |.::.:|||:||||::..|.||:.||:||:..:..|.:|||...:|||.:|.::||.||...|.:
Human   748 YQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAM 812

  Fly   559 SVMSLLSNCGLLFLQPNVKDFFSHWL-PSVPDLSFVIFEHLLLGLKFLIHKVIHERPRWVRIGLL 622
            .|::::.||.|:.....::..|. || |....:|.|:.||..|.||:|||..|.:.|.||...:.
Human   813 GVLAIVVNCYLIGQCGQLQRLFP-WLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMA 876

  Fly   623 KADFETSQALKQ 634
            |.:::..:|.|:
Human   877 KLEYQRREAFKR 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AxsNP_476777.1 Anoctamin 202..623 CDD:282414 155/640 (24%)
ANO8NP_066010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Anoctamin 237..877 CDD:398306 155/640 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..650 9/125 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 681..728 3/46 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..970 0/1 (0%)
PHA03307 <940..>1120 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 997..1152
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1232
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1263362at2759
OrthoFinder 1 1.000 - - FOG0001419
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100943
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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