Protein Alignment Axs and ANO8

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_066010.1
• Gene: ANO8 / 57719
• HGNCID: 29329
• Length: 1232
• Species: Homo sapiens
• Alignment Length: 792
• Identity: 191/792 - (24%)
• Similarity: 314/792 - (39%)
• Gaps: 258/792 - (32%)

  Fly    94 TEKY-LYLSASVDTLLRLADAAELEKMTTTHSMQKFNHG-----CISDFLLPGMGKE-------- 144
            |..| .:::|:.::|||.||...|.|....    :|..|     |..||:...:..|
Human   104 TRAYAFFVTATYESLLRGADELGLRKAVKA----EFGGGTRGFSCEEDFIYENVESELRFFTSQE 164

  Fly   145 ---------QILRYCEIPVL-----IKDVIQDGIKSYVQKGYIEDMFPLHDILYLERF--NW-NL 192
                     |.||..:...|     ::|  |..|.....:|.|:.:||:|:...|.|.  :| ..
Human   165 RQSIIRFWLQNLRAKQGEALHNVRFLED--QPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQA 227

  Fly   193 KRTKLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF--------DLNISLVCSFYV 249
            .....|::||.:|||..|.:||.::.|||.|:::|::||.:.|.|        |::..:...|.|
Human   228 VCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNV 292

  Fly   250 VWTTIFLELWKRKCAGYSYRWGTIEM--SSLDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMY 312
            :|:|:|||.|||:.|..:|:|||::.  .::::||..:.|..:..|||.....:||.....|...
Human   293 IWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQL 357

  Fly   313 CISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLT 377
            .:|.|:.|.|:|......|..||::..||:..|......::|.::.::|:::.:..|:|||.:|.
Human   358 LVSLPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIWLN 422

  Fly   378 NLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLL------- 435
            ::||:|..|.|::|.:.|::||:.||::.|.|||.|.|.|:.:||..|...|:..|.|
Human   423 DMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFLQNVREVL 487

  Fly   436 ---------------------------------------------------------CIAQEIGI 443
                                                                     |::...|.
Human   488 QPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGGGGRRCLSGGCGA 552

  Fly   444 P------------------------------------------------------LLAVLRQKYA 454
            |                                                      |...||.|..
Human   553 PEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEEEGEEGGLLDCGLRLKKV 617

  Fly   455 EFRHR--------------------------------EVAEE----------------------- 464
            .|..|                                .:|||
Human   618 SFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEEDDEAEGAPGSPEREPPAILFRRA 682

  Fly   465 ---------------KLRSISD---------------------LPRYEQSFYESGLDEYHSTYED 493
                           :..|.||                     .|:..|:..||.:.:|..|::|
Human   683 GGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTFQD 747

  Fly   494 YLQVCIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELL 558
            |.::.:|||:||||::..|.||:.||:||:..:..|.:|||...:|||.:|.::||.||...|.:
Human   748 YQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAM 812

  Fly   559 SVMSLLSNCGLLFLQPNVKDFFSHWL-PSVPDLSFVIFEHLLLGLKFLIHKVIHERPRWVRIGLL 622
            .|::::.||.|:.....::..|. || |....:|.|:.||..|.||:|||..|.:.|.||...:.
Human   813 GVLAIVVNCYLIGQCGQLQRLFP-WLSPEAAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMA 876

  Fly   623 KADFETSQALKQ 634
            |.:::..:|.|:
Human   877 KLEYQRREAFKR 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	155/640 (24%)
ANO8	NP_066010.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		Anoctamin	237..>497	CDD:461349	83/259 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..650		9/125 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..728		3/46 (7%)
		Anoctamin	<717..877	CDD:461349	57/160 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..970		0/1 (0%)
		PHA03307	<940..>1120	CDD:223039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	997..1152
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1174..1232