DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Axs and ano10a

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001025377.1	Gene:	ano10a / 566425	ZFINID:	ZDB-GENE-050913-43	Length:	646	Species:	Danio rerio

Alignment Length:	581	Identity:	210/581 - (36%)
Similarity:	318/581 - (54%)	Gaps:	66/581 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 TLLRLADAAE---LEKMTTTHSMQKF---NHGCISDFLLPGMGKEQILRYCEIPVLIK---DVIQ 161
            ||.||...||   |.|.....:|:.|   |.....||...|.|   .|...|...::|   |.::
Zfish    75 TLQRLLSGAEDVGLFKEFQDGTMRGFTYANRESFKDFEGDGEG---FLGDAECQYIVKHELDTLR 136

  Fly   162 DGIKSYV-------------------QKGYIEDMFPLHDILYLER--FNWNLKRTKL---PIEDI 202
            ...:.|:                   .||.:...||||:...|:|  |:| .|:.||   |::||
Zfish   137 AKNEEYIPGYPKYKLYPGKSIVRRLQSKGVLVQYFPLHNKEDLKRLSFSW-YKKIKLSFQPLDDI 200

  Fly   203 RNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVFDL----NISLVCSFYVVWTTIFLELWKRKC 263
            |:|||..:||||||:|::|.|||..:|.||..|:||.    ...|...|.:||:|:|||:|||..
Zfish   201 RSYFGEGLGLYFGFLEYFTFALIPMALIGIPYYLFDWEDYDKYVLFAVFNLVWSTVFLEVWKRCS 265

  Fly   264 AGYSYRWGTI-EMSSLDKPRSAYTGQLKPDPITGKMTLHYPMRYTYLQMYCISYPVVLGCVVAAG 327
            |..:|.|||: ...:.::||:.:.|.|..:|:||:....||....:|::|.:|.|.||.|:..:.
Zfish   266 ATLAYSWGTLGRKKAFEEPRAGFHGPLGLNPVTGREEPIYPSSKRHLRIYLVSVPFVLLCLYLSF 330

  Fly   328 WFALYQFQIEAEVLADF--GPD---SWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQ 387
            :..:..|.:|...::.:  .|:   |.||:||.|:.:|:|.|.:..|...|.|||:.||||..|.
Zfish   331 YVMMVYFDMEFWAISIYHENPNFATSVLLFVPSIIYAVVIEIMNLLYRYAAEFLTDWENHRLESS 395

  Fly   388 YDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLLCIAQEIGIPL-LAVLRQ 451
            :..|.|.|:::|..||.|.|.||||||:.|:..|:..|...|:..|:|....|..:|. |...|.
Zfish   396 FQNHLVPKVLVFNFVNCFASLFYIAFVMQDMVLLRQSLATLLITSQILNQVMEAFLPYWLQRRRN 460

  Fly   452 KYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAI 516
            |....|.|.:..:|     :||..||...|:.::.|..|::|||:..:.||:|.||:.|.|.||:
Zfish   461 KRVYKRMRRLMGDK-----ELPLLEQIQLETEMNTYLGTFDDYLEQFLLFGYVSLFSCVHPLAAV 520

  Fly   517 GALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQPNVKDFFS 581
            ..:|||:..|:.|.:|:|::|||||:..|.|||.||||||.:|::::::||.|:.|.|.||.:|
Zfish   521 LVVLNNITEVYSDAFKMCHVFKRPFSEPAANIGVWQLAFETMSIIAVVTNCALIALSPQVKAYF- 584

  Fly   582 HWLPSVPD------LSFVIFEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQLK 636
                  |:      |:.|..||:||..||::..||.:.|:.:::.|.|.|||:.:|||:.|
Zfish   585 ------PESDAQLILTVVAIEHVLLAFKFILAFVIPDVPKHIQVKLSKLDFESLEALKKRK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	167/437 (38%)
ano10a	NP_001025377.1	Anoctamin	200..626	CDD:282414	167/437 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1510
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14314
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2484
OMA	1	1.010	-	-		QHG57839
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	1	1.100	-	-	LDO	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4482
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840