DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Axs and ano8b

DIOPT Version :9

Sequence 1:	NP_476777.1	Gene:	Axs / 32645	FlyBaseID:	FBgn0000152	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_021335376.1	Gene:	ano8b / 562782	ZFINID:	ZDB-GENE-121024-1	Length:	1110	Species:	Danio rerio

Alignment Length:	769	Identity:	180/769 - (23%)
Similarity:	309/769 - (40%)	Gaps:	240/769 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 TEKY-LYLSASVDTLLRLADAAELEKMTTTHSMQKFNHG-----CISDFLLPGMGKE-------- 144
            |..| .:::|:.:.|||.|:...|:|..    ..:|..|     |..|::...:..|
Zfish   125 TRMYAFFVTATYENLLRGAEEMGLQKAV----KPEFGGGSRSFSCEEDYIYENIESELCFFTSQE 185

  Fly   145 --QILRYC-------------EIPVLIKDVIQDGIKSYVQKGYIEDMFPLHDILYLERFNWNLKR 194
              .|::|.             .|..|....|...:::   :|.|:.:||||:    :|....|.:
Zfish   186 RQSIIKYWLDNLRAKHGEALHNIHFLEGQPIIPELRA---RGVIQQVFPLHE----QRILGQLMK 243

  Fly   195 T-------KLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF--------DLNISLV 244
            :       |.|::||.:|||..|.:||.::.|||.::::|::.|.:.::.        |:...:.
Zfish   244 SWVQAVCEKQPLDDICDYFGVKIAMYFAWLGFYTTSMLYPAVIGFVLWMLTESDQTSRDICCVVF 308

  Fly   245 CSFYVVWTTIFLELWKRKCAGYSYRWGTIE--MSSLDKPRSAYTGQLKPDPITGKMTLHYPMRYT 307
            ..|.|||.|:|||.|||:.|..:|:|||:.  ..||::||..:.|..:..|:||....:||....
Zfish   309 ALFNVVWATLFLERWKRRGAELAYKWGTLNTPAESLEEPRPQFRGVKRCSPVTGCEEFYYPPWRR 373

  Fly   308 YLQMYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKL 372
            .:..:.:|:||.:.|:.......|..|:::..|:..........::|.|:.::.:......|.|:
Zfish   374 RVFRWLVSFPVCILCLCFVFLAMLVCFELQEFVMGIKELPRVARFIPKIMLAITVTACDEVYRKI 438

  Fly   373 ATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLLCI 437
            |.:|.::||:|.:|.|:::.:.|::||:.||::.|.|||.|.|.|:.:||..|...|::.|.:..
Zfish   439 ACWLNDMENYRLQSAYEKNLIIKMVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLIIRQFVQN 503

  Fly   438 AQEIGIPLLA--------VLRQ----------KYAEF---------------------------- 456
            .:|:..|.||        .||.          ||...
Zfish   504 MKEVLQPYLAERHRLGELTLRAVWELLVSALLKYGRLAAGRAQVSPSDPTVLGPGLRGPQMGEEG 568

  Fly   457 ---------------------------RHREVAEE---------KLRSISDLPRYEQ-------- 477
                                       ||.|...|         |||.:|.:.:.|:
Zfish   569 HQDRRERKCLNGGCGVPDEDMEEEHGERHSEEENESESLIDCGLKLRKVSFIEKVERKSASCVSP 633

  Fly   478 ---SFYESG-------------------------------------------------------- 483
               ||.|.|
Zfish   634 VDDSFLEEGSPTMVERGMDPASVFEMCDDEDENGAPEMKELAAEPLPTGVENSSSVKLRKRGRSL 698

  Fly   484 --------------------------------LDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAI 516
                                            :..|..|::||.::.:|||:||||::..|.||:
Zfish   699 ERADSKTKRDSWMDPPEEQETNTLTQAEVEGCMQTYQDTFQDYQEMFVQFGYVVLFSSAFPLAAM 763

  Fly   517 GALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQPNVKDFFS 581
            .||:||:..:..|.:|||...:|||..|..:||.||...|.:.:::::.||.|:.....::..|.
Zfish   764 CALINNIIEIRSDAFKLCTSLQRPFGLRVASIGQWQTVMEAMGLIAIIVNCYLIGQCGQLQRLFP 828

  Fly   582 HWL-PSVPDLSFVIFEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ 634
             || |.:..:|.||.||..:.||::||..|.:.|.||...:.|.:|:..:|.|:
Zfish   829 -WLSPEMAIISIVILEHFAVLLKYIIHVAIPDIPSWVGEEMAKLEFQRKEAFKK 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:282414	146/612 (24%)
ano8b	XP_021335376.1	Anoctamin	258..870	CDD:309610	146/612 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0001419
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100943
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720