Protein Alignment Axs and ano8b

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_691248.6
• Gene: ano8b / 562782
• ZFINID: ZDB-GENE-121024-1
• Length: 1110
• Species: Danio rerio
• Alignment Length: 769
• Identity: 180/769 - (23%)
• Similarity: 309/769 - (40%)
• Gaps: 240/769 - (31%)

  Fly    94 TEKY-LYLSASVDTLLRLADAAELEKMTTTHSMQKFNHG-----CISDFLLPGMGKE-------- 144
            |..| .:::|:.:.|||.|:...|:|..    ..:|..|     |..|::...:..|
Zfish   125 TRMYAFFVTATYENLLRGAEEMGLQKAV----KPEFGGGSRSFSCEEDYIYENIESELCFFTSQE 185

  Fly   145 --QILRYC-------------EIPVLIKDVIQDGIKSYVQKGYIEDMFPLHDILYLERFNWNLKR 194
              .|::|.             .|..|....|...:::   :|.|:.:||||:    :|....|.:
Zfish   186 RQSIIKYWLDNLRAKHGEALHNIHFLEGQPIIPELRA---RGVIQQVFPLHE----QRILGQLMK 243

  Fly   195 T-------KLPIEDIRNYFGSSIGLYFGFIEFYTKALIFPSLFGILQYVF--------DLNISLV 244
            :       |.|::||.:|||..|.:||.::.|||.::::|::.|.:.::.        |:...:.
Zfish   244 SWVQAVCEKQPLDDICDYFGVKIAMYFAWLGFYTTSMLYPAVIGFVLWMLTESDQTSRDICCVVF 308

  Fly   245 CSFYVVWTTIFLELWKRKCAGYSYRWGTIE--MSSLDKPRSAYTGQLKPDPITGKMTLHYPMRYT 307
            ..|.|||.|:|||.|||:.|..:|:|||:.  ..||::||..:.|..:..|:||....:||....
Zfish   309 ALFNVVWATLFLERWKRRGAELAYKWGTLNTPAESLEEPRPQFRGVKRCSPVTGCEEFYYPPWRR 373

  Fly   308 YLQMYCISYPVVLGCVVAAGWFALYQFQIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKL 372
            .:..:.:|:||.:.|:.......|..|:::..|:..........::|.|:.::.:......|.|:
Zfish   374 RVFRWLVSFPVCILCLCFVFLAMLVCFELQEFVMGIKELPRVARFIPKIMLAITVTACDEVYRKI 438

  Fly   373 ATFLTNLENHRTRSQYDRHRVNKLMLFEIVNNFFSQFYIAFVLHDLRQLKYQLMMQLLVFQLLCI 437
            |.:|.::||:|.:|.|:::.:.|::||:.||::.|.|||.|.|.|:.:||..|...|::.|.:..
Zfish   439 ACWLNDMENYRLQSAYEKNLIIKMVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLIIRQFVQN 503

  Fly   438 AQEIGIPLLA--------VLRQ----------KYAEF---------------------------- 456
            .:|:..|.||        .||.          ||...
Zfish   504 MKEVLQPYLAERHRLGELTLRAVWELLVSALLKYGRLAAGRAQVSPSDPTVLGPGLRGPQMGEEG 568

  Fly   457 ---------------------------RHREVAEE---------KLRSISDLPRYEQ-------- 477
                                       ||.|...|         |||.:|.:.:.|:
Zfish   569 HQDRRERKCLNGGCGVPDEDMEEEHGERHSEEENESESLIDCGLKLRKVSFIEKVERKSASCVSP 633

  Fly   478 ---SFYESG-------------------------------------------------------- 483
               ||.|.|
Zfish   634 VDDSFLEEGSPTMVERGMDPASVFEMCDDEDENGAPEMKELAAEPLPTGVENSSSVKLRKRGRSL 698

  Fly   484 --------------------------------LDEYHSTYEDYLQVCIQFGFVVLFAAVAPFAAI 516
                                            :..|..|::||.::.:|||:||||::..|.||:
Zfish   699 ERADSKTKRDSWMDPPEEQETNTLTQAEVEGCMQTYQDTFQDYQEMFVQFGYVVLFSSAFPLAAM 763

  Fly   517 GALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMSLLSNCGLLFLQPNVKDFFS 581
            .||:||:..:..|.:|||...:|||..|..:||.||...|.:.:::::.||.|:.....::..|.
Zfish   764 CALINNIIEIRSDAFKLCTSLQRPFGLRVASIGQWQTVMEAMGLIAIIVNCYLIGQCGQLQRLFP 828

  Fly   582 HWL-PSVPDLSFVIFEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ 634
             || |.:..:|.||.||..:.||::||..|.:.|.||...:.|.:|:..:|.|:
Zfish   829 -WLSPEMAIISIVILEHFAVLLKYIIHVAIPDIPSWVGEEMAKLEFQRKEAFKK 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	146/612 (24%)
ano8b	XP_691248.6	Anoctamin	258..870	CDD:461349	146/612 (24%)