Protein Alignment Axs and ano7

DIOPT Version :10

• Sequence 1: NP_476777.1
• Gene: Axs / 32645
• FlyBaseID: FBgn0000152
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_009289708.1
• Gene: ano7 / 556876
• ZFINID: ZDB-GENE-130530-576
• Length: 883
• Species: Danio rerio
• Alignment Length: 771
• Identity: 173/771 - (22%)
• Similarity: 296/771 - (38%)
• Gaps: 236/771 - (30%)

  Fly    79 IQEFGI-QTTLEIV-GKTE-KYLYLSASVDTLLRLADAAELE---KMTTTHSMQKFNHGCISDFL 137
            :||.|: |...|:| |||: .|:.|||..:.|...|:...|.   ::.|| .:..::...:....
Zfish    90 LQEAGLHQEMKEVVQGKTKTTYVLLSAPWNVLCYYAEEISLRVPLQVVTT-PISNWSETILEKLH 153

  Fly   138 LPGMGKEQILRY------CEIPV-----------------------LIKDVI-----------QD 162
            :|.:..:.:..|      |....                       ::.:::           :.
Zfish   154 IPNIMAQDVPNYPPDYYTCPFRTTKLERFLGHENKDTFFKTTQRHQILYEILARTPYGALKRGEV 218

  Fly   163 GIKSYVQKGYIEDMFPLHD-------------------ILYLERFNWNLKRTKLPIEDIRNYFGS 208
            ||...|.:..:...||||:                   ||:.....|...|...|::.||.|||.
Zfish   219 GIGRLVSEKVLTAAFPLHEGPFQLPKTQEDPQCLNMRQILHHYWARWACWRKYQPLDHIREYFGE 283

  Fly   209 SIGLYFGFIEFYTKALIFPS--------LFGILQYVFDL------------------------NI 241
            .|.|||.::.|||..|: |:        ||||...|.|:                        |:
Zfish   284 KIALYFAWLGFYTGWLL-PAAVVGFIIFLFGIWLMVTDVPAEELCSSGNAFIMCPLCNICSHWNL 347

  Fly   242 SLVC------------------SFYVVWTTIFLELWKRKCAGYSYRWGTIEMSSL-DKPRSAYTG 287
            |.:|                  .|..:|...|||.|||..:..|:||...|...: ::||..:|.
Zfish   348 SSICYTYKAGLLFDNGGTVFFSIFMSLWAVTFLEYWKRTSSILSHRWDCSEFEEIEERPRPEFTA 412

  Fly   288 QLKP----DPITGKMTLHYP--------------------MRYTYLQMYCISYPVVLGCVVAAGW 328
             |.|    :|:||....::|                    :...:| |..|.|..:|..::....
Zfish   413 -LAPMTVRNPVTGAEEPYFPEARRLSRTLTGNMVIILMISIVLIFL-MAIILYRTILSIIIYRSQ 475

  Fly   329 FALYQFQIEAEVLADFGPDSWLLYVPVIVQSVLIAIFSWAYEKLATFLTNLENHRTRSQYDRHRV 393
            .|.:.|  .|..:|..        ...::..::|.:.|..|..||..||..|.|||:::|:...:
Zfish   476 SAFFIF--SAGRIASL--------TGSMLNLLVILLLSRLYTYLAQCLTRWEMHRTQTEYENAFI 530

  Fly   394 NKLMLFEIVNNFFSQFYIAF-------------VLHDLR-----------QLKYQLMMQLLVFQL 434
            .|:.:|:.||.:.|..||||             .|..:|           :|..:|::.::..|:
Zfish   531 LKVFIFQFVNFYSSPVYIAFFKGRFVGYPGSYNTLLGIRNEDCGASGCLIELAQELLVIMVGKQV 595

  Fly   435 LCIAQEIGIPLLAVL--RQKYAEFRHREVAEEKLRSISDLPRYEQSFYESGLDEYHSTYEDYLQV 497
            :...||..:|.|...  ::|....|.:||.:|. .:.|.:..:|..:.   |......:::||::
Zfish   596 ISNIQEFVLPKLKTWWHKRKLKPARSQEVIDEP-DTNSQINPWENDYQ---LLVCEGLFDEYLEM 656

  Fly   498 CIQFGFVVLFAAVAPFAAIGALLNNVFAVHIDMWKLCNIFKRPFARRAKNIGAWQLAFELLSVMS 562
            .:||||:.:|.|..|.|.:.||:||...|.:|..|....::||...||::||.|....:.:|.::
Zfish   657 VLQFGFITIFVAACPLAPLFALINNWVEVRLDAQKFVCEYRRPVVERAQDIGIWLTILQFISYLA 721

  Fly   563 LLSNCGLL---------------------------------FLQ---------------PNVKDF 579
            ::||..|:                                 |.|               .|.:|:
Zfish   722 VISNAFLIAFTSDFLPRLFYRYTAGSMSGYINFTLSVAPANFTQNEMSCRYRGLRDEKGQNTQDY 786

  Fly   580 FSHWLPSVPDLSFV-IFEHLLLGLKFLIHKVIHERPRWVRIGLLKADFETSQALKQ 634
            : |.|  ...|||| ||||::|.:..:|..::.:.|..|.|.:.:..:...:||.:
Zfish   787 Y-HLL--AIRLSFVIIFEHVVLLIGRIIDWIVPDIPEEVEIKIKREHYMAKEALAE 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Axs	NP_476777.1	Anoctamin	202..623	CDD:461349	138/570 (24%)
ano7	XP_009289708.1	Anoct_dimer	42..274	CDD:465044	32/184 (17%)
		Anoctamin	277..829	CDD:461349	138/571 (24%)